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• W2554592783 abstract "Thyroid hormone concentrations only become sufficient to maintain a euthyroid state through appropriate stimulation by pituitary TSH. In such a dynamic system under constant high pressure, guarding against overstimulation becomes vital. Therefore, several defensive mechanisms protect against accidental overstimulation, such as plasma protein binding, conversion of T4 into the more active T3, active transmembrane transport, counter-regulatory activities of reverse T3 and thyronamines and negative hypothalamic-pituitary-thyroid feedback control of TSH. TSH has gained a dominant but misguided role in interpreting thyroid function testing in assuming that its exceptional sensitivity thereby translates into superior diagnostic performance. However, TSH-dependent thyroid disease classification is heavily influenced by statistical analytic techniques such as uni- or multivariate-defined normality. This demands a separation of its conjoint roles as a sensitive screening test and accurate diagnostic tool. Homeostatic equilibria (set points) in healthy subjects are less variable, and do not follow a pattern of random variation, rather indicating signs of early and progressive homeostatic control across the euthyroid range. In the event of imminent thyroid failure with a reduced FT4 output per unit TSH, conversion efficiency increases in order to maintain FT3 stability. In such situations, T3 stability takes priority over set point maintenance. This suggests a concept of relational stability. These findings have important implications for both TSH reference limits and treatment targets for patients on levothyroxine. The use of archival markers is proposed to facilitate the homeostatic interpretation of all parameters." @default.
• W2554592783 created "2016-11-30" @default.
• W2554592783 creator A5009178279 @default.
• W2554592783 creator A5067369643 @default.
• W2554592783 creator A5070080506 @default.
• W2554592783 creator A5074292475 @default.
• W2554592783 date "2016-11-07" @default.
• W2554592783 modified "2023-10-09" @default.
• W2554592783 title "Relational Stability in the Expression of Normality, Variation, and Control of Thyroid Function" @default.
• W2554592783 cites W144158651 @default.
• W2554592783 cites W1554650193 @default.
• W2554592783 cites W1594076929 @default.
• W2554592783 cites W1602307529 @default.
• W2554592783 cites W1747119434 @default.
• W2554592783 cites W1755861491 @default.
• W2554592783 cites W1822568199 @default.
• W2554592783 cites W1904294385 @default.
• W2554592783 cites W1934330082 @default.
• W2554592783 cites W1966433579 @default.
• W2554592783 cites W1970942447 @default.
• W2554592783 cites W1975671863 @default.
• W2554592783 cites W1976734397 @default.
• W2554592783 cites W1978957229 @default.
• W2554592783 cites W1980687578 @default.
• W2554592783 cites W1986793251 @default.
• W2554592783 cites W1987993826 @default.
• W2554592783 cites W1991454487 @default.
• W2554592783 cites W1994901177 @default.
• W2554592783 cites W1995940066 @default.
• W2554592783 cites W1999060428 @default.
• W2554592783 cites W2001699369 @default.
• W2554592783 cites W2003717204 @default.
• W2554592783 cites W2003898179 @default.
• W2554592783 cites W2003982930 @default.
• W2554592783 cites W2004260518 @default.
• W2554592783 cites W2008391847 @default.
• W2554592783 cites W2009810638 @default.
• W2554592783 cites W2016074473 @default.
• W2554592783 cites W2020249822 @default.
• W2554592783 cites W2021932599 @default.
• W2554592783 cites W2023259089 @default.
• W2554592783 cites W2024050661 @default.
• W2554592783 cites W2033555047 @default.
• W2554592783 cites W2034042210 @default.
• W2554592783 cites W2045738888 @default.
• W2554592783 cites W2047159776 @default.
• W2554592783 cites W2047401113 @default.
• W2554592783 cites W2049346955 @default.
• W2554592783 cites W2056366718 @default.
• W2554592783 cites W2060906056 @default.
• W2554592783 cites W2062744500 @default.
• W2554592783 cites W2063068406 @default.
• W2554592783 cites W2065359672 @default.
• W2554592783 cites W2071227705 @default.
• W2554592783 cites W2073346341 @default.
• W2554592783 cites W2077432447 @default.
• W2554592783 cites W2078758314 @default.
• W2554592783 cites W2089663726 @default.
• W2554592783 cites W2089891688 @default.
• W2554592783 cites W2090100356 @default.
• W2554592783 cites W2093253556 @default.
• W2554592783 cites W2096162365 @default.
• W2554592783 cites W2097165278 @default.
• W2554592783 cites W2099864259 @default.
• W2554592783 cites W2100049277 @default.
• W2554592783 cites W2101607054 @default.
• W2554592783 cites W2104878795 @default.
• W2554592783 cites W2108218509 @default.
• W2554592783 cites W2116353330 @default.
• W2554592783 cites W2118758311 @default.
• W2554592783 cites W2121412391 @default.
• W2554592783 cites W2121784884 @default.
• W2554592783 cites W2127465871 @default.
• W2554592783 cites W2128789027 @default.
• W2554592783 cites W2131416923 @default.
• W2554592783 cites W2131585813 @default.
• W2554592783 cites W2134856350 @default.
• W2554592783 cites W2136343353 @default.
• W2554592783 cites W2144432321 @default.
• W2554592783 cites W2147656324 @default.
• W2554592783 cites W2148247134 @default.
• W2554592783 cites W2150256230 @default.
• W2554592783 cites W2152373564 @default.
• W2554592783 cites W2153024016 @default.
• W2554592783 cites W2156565888 @default.
• W2554592783 cites W2163022463 @default.
• W2554592783 cites W2164480362 @default.
• W2554592783 cites W2164751104 @default.
• W2554592783 cites W2164942675 @default.
• W2554592783 cites W2165257553 @default.
• W2554592783 cites W2166544976 @default.
• W2554592783 cites W2166619307 @default.
• W2554592783 cites W2170006972 @default.
• W2554592783 cites W2173996299 @default.
• W2554592783 cites W2177288738 @default.
• W2554592783 cites W2199136101 @default.
• W2554592783 cites W2201239534 @default.
• W2554592783 cites W2226014380 @default.
• W2554592783 cites W2248488609 @default.
• W2554592783 cites W2268590110 @default.

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