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- W2554619763 abstract "E. coli is a multifaceted pathogen of major significance to global human health and an important contributor to increasing antibiotic resistance. Given the paucity of therapies still effective against multidrug-resistant pathogenic E. coli strains, novel treatment and prevention strategies are urgently required. In this study, we defined the core and accessory components of the E. coli genome by examining a large collection of draft and completely sequenced strains available from public databases. This data set was mined by employing a reverse-vaccinology approach in combination with proteomics to identify putative broadly protective vaccine antigens. One such antigen was identified that was highly immunogenic and induced protection in a mouse model of bacteremia. Overall, our study provides a genomic and proteomic framework for the selection of novel vaccine antigens that could mediate broad protection against pathogenic E. coli ." @default.
- W2554619763 created "2016-11-30" @default.
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- W2554619763 date "2016-12-28" @default.
- W2554619763 modified "2023-09-25" @default.
- W2554619763 title "A Novel Protective Vaccine Antigen from the Core Escherichia coli Genome" @default.
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- W2554619763 doi "https://doi.org/10.1128/msphere.00326-16" @default.
- W2554619763 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5120174" @default.
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