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- W2554792244 endingPage "e1006007" @default.
- W2554792244 startingPage "e1006007" @default.
- W2554792244 abstract "The mechanisms underlying human cytomegalovirus (HCMV) latency remain incompletely understood. Here, we showed that a HCMV-encoded miRNA, miR-UL148D, robustly accumulates during late stages of experimental latent HCMV infection in host cells and promotes HCMV latency by modulating the immediate early response gene 5 (IER5)-cell division cycle 25B (CDC25B) axis in host cells. miR-UL148D inhibited IER5 expression by directly targeting the three-prime untranslated region(3'UTR) of IER5 mRNA and thus rescued CDC25B expression during the establishment of viral latency. Infection with NR-1ΔmiR-UL148D, a derivative of the HCMV clinical strain NR-1 with a miR-UL148D knockout mutation, resulted in sustained induction of IER5 expression but decreased CDC25B expression in host cells. Mechanistically, we further showed that CDC25B plays an important role in suppressing HCMV IE1 and lytic gene transcription by activating cyclin-dependent kinase 1 (CDK-1). Both gain-of-function and lose-of-function assays demonstrated that miR-UL148D promotes HCMV latency by helping maintain CDC25B activity in host cells. These results provide a novel mechanism through which a HCMV miRNA regulates viral latency." @default.
- W2554792244 created "2016-11-30" @default.
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- W2554792244 creator A5082076770 @default.
- W2554792244 date "2016-11-08" @default.
- W2554792244 modified "2023-10-17" @default.
- W2554792244 title "Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5" @default.
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- W2554792244 doi "https://doi.org/10.1371/journal.ppat.1006007" @default.
- W2554792244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5100954" @default.
- W2554792244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27824944" @default.
- W2554792244 hasPublicationYear "2016" @default.
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