Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554800029> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2554800029 abstract "Dihydrofolate reductase (DHFR) inhibitors have proved to be of value as antibacterial, antimalarial, and antitumor agents. Some 2,4–diamino–5–methyl–6–[(substituted anilino)methyl]pyrrido[2,3–d]pyrimidines were reported earlier as DHFR inhibitors. Using non–parabolic Hansch models, a QSAR study was performed in an attempt to find out the required physicochemical and structural features of these compounds for DHFR inhibition. This study revealed the importance of resonance effect at R2 and R3 positions and sum of molar refractivity (6MR) at R2, R3, R4, and R5 positions of the ring C. Lipophilicity of the whole molecule (log P) also played an important role. The presence of OCH3 group at R4 of the phenyl C ring and CH3 at R1 of anilino N might be advantageous to DHFR inhibition. This QSAR study is beneficial for future studies to carry out further tailoring of this type of compounds with an objective to increase DHFR inhibitory activity." @default.
- W2554800029 created "2016-11-30" @default.
- W2554800029 creator A5038249399 @default.
- W2554800029 creator A5047178361 @default.
- W2554800029 creator A5049159180 @default.
- W2554800029 creator A5072437390 @default.
- W2554800029 date "2003-01-01" @default.
- W2554800029 modified "2023-09-27" @default.
- W2554800029 title "QSAR Study on Some Dihydrofolate Reductase Inhibitors" @default.
- W2554800029 cites W1501372585 @default.
- W2554800029 cites W1516366344 @default.
- W2554800029 cites W1965269646 @default.
- W2554800029 cites W1966700668 @default.
- W2554800029 cites W1976747112 @default.
- W2554800029 cites W1991022352 @default.
- W2554800029 cites W1996640807 @default.
- W2554800029 cites W2013439046 @default.
- W2554800029 cites W2022331577 @default.
- W2554800029 cites W2023418406 @default.
- W2554800029 cites W2027158545 @default.
- W2554800029 cites W2042001883 @default.
- W2554800029 cites W2045477579 @default.
- W2554800029 cites W2048669757 @default.
- W2554800029 cites W2059614919 @default.
- W2554800029 cites W2062191526 @default.
- W2554800029 cites W2071012843 @default.
- W2554800029 cites W2090183541 @default.
- W2554800029 cites W2106951092 @default.
- W2554800029 cites W2186943334 @default.
- W2554800029 cites W2398813974 @default.
- W2554800029 cites W2410831989 @default.
- W2554800029 cites W2473628807 @default.
- W2554800029 cites W2552376740 @default.
- W2554800029 hasPublicationYear "2003" @default.
- W2554800029 type Work @default.
- W2554800029 sameAs 2554800029 @default.
- W2554800029 citedByCount "2" @default.
- W2554800029 crossrefType "journal-article" @default.
- W2554800029 hasAuthorship W2554800029A5038249399 @default.
- W2554800029 hasAuthorship W2554800029A5047178361 @default.
- W2554800029 hasAuthorship W2554800029A5049159180 @default.
- W2554800029 hasAuthorship W2554800029A5072437390 @default.
- W2554800029 hasConcept C164126121 @default.
- W2554800029 hasConcept C178790620 @default.
- W2554800029 hasConcept C181199279 @default.
- W2554800029 hasConcept C185592680 @default.
- W2554800029 hasConcept C201399114 @default.
- W2554800029 hasConcept C2780378348 @default.
- W2554800029 hasConcept C2780708107 @default.
- W2554800029 hasConcept C2781320022 @default.
- W2554800029 hasConcept C32909587 @default.
- W2554800029 hasConcept C55493867 @default.
- W2554800029 hasConcept C71240020 @default.
- W2554800029 hasConceptScore W2554800029C164126121 @default.
- W2554800029 hasConceptScore W2554800029C178790620 @default.
- W2554800029 hasConceptScore W2554800029C181199279 @default.
- W2554800029 hasConceptScore W2554800029C185592680 @default.
- W2554800029 hasConceptScore W2554800029C201399114 @default.
- W2554800029 hasConceptScore W2554800029C2780378348 @default.
- W2554800029 hasConceptScore W2554800029C2780708107 @default.
- W2554800029 hasConceptScore W2554800029C2781320022 @default.
- W2554800029 hasConceptScore W2554800029C32909587 @default.
- W2554800029 hasConceptScore W2554800029C55493867 @default.
- W2554800029 hasConceptScore W2554800029C71240020 @default.
- W2554800029 hasLocation W25548000291 @default.
- W2554800029 hasOpenAccess W2554800029 @default.
- W2554800029 hasPrimaryLocation W25548000291 @default.
- W2554800029 hasRelatedWork W117510796 @default.
- W2554800029 hasRelatedWork W1982190063 @default.
- W2554800029 hasRelatedWork W2071012843 @default.
- W2554800029 hasRelatedWork W2088639688 @default.
- W2554800029 hasRelatedWork W2117694142 @default.
- W2554800029 hasRelatedWork W2129725189 @default.
- W2554800029 hasRelatedWork W2366898232 @default.
- W2554800029 hasRelatedWork W2396866348 @default.
- W2554800029 hasRelatedWork W2509999580 @default.
- W2554800029 hasRelatedWork W2579982412 @default.
- W2554800029 hasRelatedWork W2730733748 @default.
- W2554800029 hasRelatedWork W2745677743 @default.
- W2554800029 hasRelatedWork W2776264081 @default.
- W2554800029 hasRelatedWork W2808587992 @default.
- W2554800029 hasRelatedWork W2949720518 @default.
- W2554800029 hasRelatedWork W2949919622 @default.
- W2554800029 hasRelatedWork W2951554058 @default.
- W2554800029 hasRelatedWork W3096104002 @default.
- W2554800029 hasRelatedWork W3112719314 @default.
- W2554800029 hasRelatedWork W3134031880 @default.
- W2554800029 isParatext "false" @default.
- W2554800029 isRetracted "false" @default.
- W2554800029 magId "2554800029" @default.
- W2554800029 workType "article" @default.