Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554870140> ?p ?o ?g. }
- W2554870140 endingPage "862" @default.
- W2554870140 startingPage "853" @default.
- W2554870140 abstract "Serine protease inhibitors (serpins) in insects function within development, wound healing and immunity. The genome of the African malaria vector, Anopheles gambiae , encodes 23 distinct serpin proteins, several of which are implicated in disease-relevant physiological responses. A. gambiae serpin 18 (SRPN18) was previously categorized as non-inhibitory based on the sequence of its reactive-center loop (RCL), a region responsible for targeting and initiating protease inhibition. The crystal structure of A. gambiae SRPN18 was determined to a resolution of 1.45 Å, including nearly the entire RCL in one of the two molecules in the asymmetric unit. The structure reveals that the SRPN18 RCL is extremely short and constricted, a feature associated with noncanonical inhibitors or non-inhibitory serpin superfamily members. Furthermore, the SRPN18 RCL does not contain a suitable protease target site and contains a large number of prolines. The SRPN18 structure therefore reveals a unique RCL architecture among the highly conserved serpin fold." @default.
- W2554870140 created "2016-11-30" @default.
- W2554870140 creator A5000102260 @default.
- W2554870140 creator A5006651636 @default.
- W2554870140 creator A5014977479 @default.
- W2554870140 creator A5037624700 @default.
- W2554870140 creator A5044048611 @default.
- W2554870140 date "2016-11-19" @default.
- W2554870140 modified "2023-09-26" @default.
- W2554870140 title "1.45 Å resolution structure of SRPN18 from the malaria vector<i>Anopheles gambiae</i>" @default.
- W2554870140 cites W109623845 @default.
- W2554870140 cites W1595226937 @default.
- W2554870140 cites W18116789 @default.
- W2554870140 cites W1912762104 @default.
- W2554870140 cites W1969547178 @default.
- W2554870140 cites W1969672293 @default.
- W2554870140 cites W1971890412 @default.
- W2554870140 cites W1974607999 @default.
- W2554870140 cites W1976193976 @default.
- W2554870140 cites W1978096114 @default.
- W2554870140 cites W1979444649 @default.
- W2554870140 cites W1981308792 @default.
- W2554870140 cites W1981730570 @default.
- W2554870140 cites W1984127145 @default.
- W2554870140 cites W1988694095 @default.
- W2554870140 cites W1993395700 @default.
- W2554870140 cites W1995283263 @default.
- W2554870140 cites W1996362995 @default.
- W2554870140 cites W2001790577 @default.
- W2554870140 cites W2003546514 @default.
- W2554870140 cites W2004360551 @default.
- W2554870140 cites W2005321572 @default.
- W2554870140 cites W2007219751 @default.
- W2554870140 cites W2008161233 @default.
- W2554870140 cites W2011955429 @default.
- W2554870140 cites W2013776818 @default.
- W2554870140 cites W2014694459 @default.
- W2554870140 cites W2015591259 @default.
- W2554870140 cites W2019240734 @default.
- W2554870140 cites W2027766635 @default.
- W2554870140 cites W2032615313 @default.
- W2554870140 cites W2034350906 @default.
- W2554870140 cites W2036430692 @default.
- W2554870140 cites W2037065629 @default.
- W2554870140 cites W2037939267 @default.
- W2554870140 cites W2040356924 @default.
- W2554870140 cites W2042279556 @default.
- W2554870140 cites W2043924467 @default.
- W2554870140 cites W2045022133 @default.
- W2554870140 cites W2045130546 @default.
- W2554870140 cites W2046574852 @default.
- W2554870140 cites W2046595618 @default.
- W2554870140 cites W2055324984 @default.
- W2554870140 cites W2057701454 @default.
- W2554870140 cites W2059222613 @default.
- W2554870140 cites W2061543317 @default.
- W2554870140 cites W2064095852 @default.
- W2554870140 cites W2071363357 @default.
- W2554870140 cites W2071597062 @default.
- W2554870140 cites W2074808887 @default.
- W2554870140 cites W2078119200 @default.
- W2554870140 cites W2078668071 @default.
- W2554870140 cites W2079613174 @default.
- W2554870140 cites W2079859332 @default.
- W2554870140 cites W2081387319 @default.
- W2554870140 cites W2082213605 @default.
- W2554870140 cites W2084196626 @default.
- W2554870140 cites W2086088001 @default.
- W2554870140 cites W2086487704 @default.
- W2554870140 cites W2086553263 @default.
- W2554870140 cites W2092524923 @default.
- W2554870140 cites W2094477253 @default.
- W2554870140 cites W2095487188 @default.
- W2554870140 cites W2103659092 @default.
- W2554870140 cites W2105408177 @default.
- W2554870140 cites W2107583985 @default.
- W2554870140 cites W2108921801 @default.
- W2554870140 cites W2108959691 @default.
- W2554870140 cites W2110216107 @default.
- W2554870140 cites W2110290441 @default.
- W2554870140 cites W2112200653 @default.
- W2554870140 cites W2112319570 @default.
- W2554870140 cites W2112994024 @default.
- W2554870140 cites W2114562248 @default.
- W2554870140 cites W2115492974 @default.
- W2554870140 cites W2115888129 @default.
- W2554870140 cites W2122994276 @default.
- W2554870140 cites W2124026197 @default.
- W2554870140 cites W2125912444 @default.
- W2554870140 cites W2131596823 @default.
- W2554870140 cites W2133420109 @default.
- W2554870140 cites W2135422286 @default.
- W2554870140 cites W2136104403 @default.
- W2554870140 cites W2140339735 @default.
- W2554870140 cites W2147874841 @default.
- W2554870140 cites W2150386615 @default.
- W2554870140 cites W2154714625 @default.
- W2554870140 cites W2162244749 @default.