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• W2554879247 abstract "Previous behavioral studies demonstrated that depressed individuals have difficulties in forgetting unwanted, especially negative, event. However, inconsistent results still exit and the neural mechanism of this phenomenon has not been investigated. This study examined the intentional memory facilitation/suppression of negative and neutral materials in depression using Think/No-Think paradigm. We found that compared with nondepressed group, depressed group recalled more negative items, irrespective of either Think or No-Think instructions. Accordingly, the frontal N2 (reflecting voluntary memory inhibition) and parietal late positive component (LPC) (reflecting conscious recollection) showed deflection for negative items in depressed compared with nondepressed participants. On the one hand, the reduced N2 for negative No-Think items indicated that depressed individuals have low motivation to suppress negative items so intentional forgetting is less successful for mood-congruent events. On the other hand, the enhanced LPC for negative Think items suggested that negative memories are excessively revisited by depressed participants (compared with nondepressed ones) due to their mood-congruent and intrusive nature. Thus we demonstrated that depressed individuals show behavioral and ERP deviations from healthy controls for both voluntary suppression and conscious retrieval of negative memory; the two abnormalities of memory control together contribute to the difficulties in forgetting negative material in depression." @default.
• W2554879247 created "2016-11-30" @default.
• W2554879247 creator A5003670403 @default.
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• W2554879247 date "2016-11-18" @default.
• W2554879247 modified "2023-10-13" @default.
• W2554879247 title "Neural correlates underlying impaired memory facilitation and suppression of negative material in depression" @default.
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• W2554879247 doi "https://doi.org/10.1038/srep37556" @default.
• W2554879247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5114610" @default.
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• W2554879247 hasPublicationYear "2016" @default.
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