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• W2554908526 abstract "Summary There is increasing evidence to suggest that reactive oxygen species play a pilot role in the pathophysiology of renal ischemia/reperfusion injury. This study was designed to investigate the antioxidant activity of Benincasa hispida on renal ischemia/reperfusion injury in rat. In experimental methodology, both the renal pedicles were occluded for 60 min followed by 24 h of reperfusion. Benincasa hispida was administered orally for five days prior to induction of renal ischemia and were continuing for one day after ischemia. At the end of the reperfusion period, rats were sacrificed. Sham operated rats followed same procedure except renal arteries occlusion. Lipid peroxidation and antioxidant enzymes were measured in renal tissue. Serum creatinine, urea and uric acid levels were measured for the evaluation of renal function. In ischemia/reperfusion rats, malondehyde content were increased significantly when compared with sham control rats. Antioxidant enzymes like superoxide dismutase, catalase and reduced glutathione level were decrease significantly as compared to sham control rat. Benincasa hispida could attenuate the heightened malondehyde levels. Ischemia/reperfusion induced antioxidant enzymes depletion was markedly increase by administration of Benincasa hispida. These results indicate that Benincasa hispida attenuate renal damage after Ischemia/reperfusion injury of the kidney by potent antioxidant activity." @default.
• W2554908526 created "2016-11-30" @default.
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• W2554908526 date "2009-01-01" @default.
• W2554908526 modified "2023-09-24" @default.
• W2554908526 title "ANTIOXIDANT ACTIVITY OF BENINCASA HISPIDA ON RENAL ISCHEMIA/REPERFUSION INJURY" @default.
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