Matches in SemOpenAlex for { <https://semopenalex.org/work/W2554938823> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2554938823 abstract "Introduction: Inhaled glucocorticoids (corticosteroids) act on the glucocorticoid receptor (GR, NR3C1) to control inflammation in asthma by reducing the expression of inflammatory genes. This may involve direct repression of inflammatory gene transcription by GR and induction of anti-inflammatory genes. However, GR is a transcription factor that induces the expression of many genes, including other transcription factors. Aims: To characterize the expression of transcriptional regulators that are induced by glucocorticoids in airway epithelial cells and in the airways. Methods: Gene expression profiling of RNA from: i) primary human bronchial epithelial cells; ii) pulmonary A549 epithelial cells; and iii) BEAS-2B cells following budesonide treatment was performed using Affymetrix PrimeView microarrays. Data was compared to that from biopsies of healthy individuals 6 h following a single dose of inhaled budesonide. Selected genes were validated by qPCR. Results: Gene ontology showed up to 20% of genes upregulated by budesonide treatment in the human airways as being involved in transcription control and many of these were common with the epithelial cells. Expression of CEBPD, FOXO3, HIF3A, KLF9, KLF15, PER1, TFCP2L1, TSC22D3 and ZBTB16 were significantly upregulated in the biopsy samples and in HBE cells, with some variability between A549 and BEAS-2B, or other structural cells. Conclusion: The large number of transcriptional regulators induced by glucocorticoids indicates key roles in mediating downstream responses. Mechanistic studies are required to identify roles for these factors in the desirable therapeutic effects and/or unwanted side effects of glucocorticoids." @default.
- W2554938823 created "2016-11-30" @default.
- W2554938823 creator A5029497606 @default.
- W2554938823 creator A5032732504 @default.
- W2554938823 creator A5068506060 @default.
- W2554938823 creator A5075828416 @default.
- W2554938823 date "2016-09-01" @default.
- W2554938823 modified "2023-09-27" @default.
- W2554938823 title "Glucocorticoid-induced transcriptional regulators in human airway cells and airways" @default.
- W2554938823 doi "https://doi.org/10.1183/13993003.congress-2016.pa3988" @default.
- W2554938823 hasPublicationYear "2016" @default.
- W2554938823 type Work @default.
- W2554938823 sameAs 2554938823 @default.
- W2554938823 citedByCount "0" @default.
- W2554938823 crossrefType "proceedings-article" @default.
- W2554938823 hasAuthorship W2554938823A5029497606 @default.
- W2554938823 hasAuthorship W2554938823A5032732504 @default.
- W2554938823 hasAuthorship W2554938823A5068506060 @default.
- W2554938823 hasAuthorship W2554938823A5075828416 @default.
- W2554938823 hasConcept C104317684 @default.
- W2554938823 hasConcept C127561419 @default.
- W2554938823 hasConcept C142724271 @default.
- W2554938823 hasConcept C150194340 @default.
- W2554938823 hasConcept C203014093 @default.
- W2554938823 hasConcept C27153228 @default.
- W2554938823 hasConcept C2776042228 @default.
- W2554938823 hasConcept C2776136866 @default.
- W2554938823 hasConcept C2780841215 @default.
- W2554938823 hasConcept C502942594 @default.
- W2554938823 hasConcept C529295009 @default.
- W2554938823 hasConcept C54355233 @default.
- W2554938823 hasConcept C59493245 @default.
- W2554938823 hasConcept C71924100 @default.
- W2554938823 hasConcept C86339819 @default.
- W2554938823 hasConcept C86803240 @default.
- W2554938823 hasConcept C87568996 @default.
- W2554938823 hasConcept C95444343 @default.
- W2554938823 hasConceptScore W2554938823C104317684 @default.
- W2554938823 hasConceptScore W2554938823C127561419 @default.
- W2554938823 hasConceptScore W2554938823C142724271 @default.
- W2554938823 hasConceptScore W2554938823C150194340 @default.
- W2554938823 hasConceptScore W2554938823C203014093 @default.
- W2554938823 hasConceptScore W2554938823C27153228 @default.
- W2554938823 hasConceptScore W2554938823C2776042228 @default.
- W2554938823 hasConceptScore W2554938823C2776136866 @default.
- W2554938823 hasConceptScore W2554938823C2780841215 @default.
- W2554938823 hasConceptScore W2554938823C502942594 @default.
- W2554938823 hasConceptScore W2554938823C529295009 @default.
- W2554938823 hasConceptScore W2554938823C54355233 @default.
- W2554938823 hasConceptScore W2554938823C59493245 @default.
- W2554938823 hasConceptScore W2554938823C71924100 @default.
- W2554938823 hasConceptScore W2554938823C86339819 @default.
- W2554938823 hasConceptScore W2554938823C86803240 @default.
- W2554938823 hasConceptScore W2554938823C87568996 @default.
- W2554938823 hasConceptScore W2554938823C95444343 @default.
- W2554938823 hasLocation W25549388231 @default.
- W2554938823 hasOpenAccess W2554938823 @default.
- W2554938823 hasPrimaryLocation W25549388231 @default.
- W2554938823 hasRelatedWork W1966168105 @default.
- W2554938823 hasRelatedWork W1972231813 @default.
- W2554938823 hasRelatedWork W2007144415 @default.
- W2554938823 hasRelatedWork W2013989859 @default.
- W2554938823 hasRelatedWork W2015335367 @default.
- W2554938823 hasRelatedWork W2019252125 @default.
- W2554938823 hasRelatedWork W2024635381 @default.
- W2554938823 hasRelatedWork W2041834671 @default.
- W2554938823 hasRelatedWork W2053768374 @default.
- W2554938823 hasRelatedWork W2057392682 @default.
- W2554938823 hasRelatedWork W2061211089 @default.
- W2554938823 hasRelatedWork W2081958274 @default.
- W2554938823 hasRelatedWork W2085583227 @default.
- W2554938823 hasRelatedWork W2142532422 @default.
- W2554938823 hasRelatedWork W2174031765 @default.
- W2554938823 hasRelatedWork W2338287064 @default.
- W2554938823 hasRelatedWork W2605219304 @default.
- W2554938823 hasRelatedWork W2886895281 @default.
- W2554938823 hasRelatedWork W3146732886 @default.
- W2554938823 hasRelatedWork W1838740776 @default.
- W2554938823 isParatext "false" @default.
- W2554938823 isRetracted "false" @default.
- W2554938823 magId "2554938823" @default.
- W2554938823 workType "article" @default.