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- W2554962016 endingPage "115" @default.
- W2554962016 startingPage "66" @default.
- W2554962016 abstract "Peptides have served as a versatile tool in a broad range of biomedical research and have been used to regulate key biochemical pathways and treat human diseases. Since endogenous peptides and peptides derived from protein sources do not often have optimal physicochemical and biological properties, a number of methods and strategies have been developed to achieve high potency and selectivity to their targets. This chapter summarizes frequently used tactics that have been employed to accomplish this end, including defining critical binding determinants, substituting with nonnatural amino acids, modifying peptide backbone structures, forming macrocycles, and stabilizing biologically active conformations." @default.
- W2554962016 created "2016-11-30" @default.
- W2554962016 creator A5021356264 @default.
- W2554962016 creator A5042498688 @default.
- W2554962016 creator A5054972559 @default.
- W2554962016 creator A5056560382 @default.
- W2554962016 creator A5081196478 @default.
- W2554962016 date "2017-01-01" @default.
- W2554962016 modified "2023-10-16" @default.
- W2554962016 title "Strategy and Tactics for Designing Analogs: Biochemical Characterization of the Large Molecules ☆" @default.
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