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• W2554986834 abstract "Telomerase extends the ends of linear chromosomes, and its expression leads to cellular immortalization. In HPV-associated cancers, telomerase is universally detected, and this occurs by activation of the catalytic subunit of telomerase, hTERT. The expression of hTERT is affected by both high-risk HPV E6 and E7. Seminal studies over the last two decades have identified the transcriptional, epigenetic, and post-transcriptional roles high-risk E6 and E7 have in telomerase regulation. This review will summarize these findings and highlight the importance of telomerase activation as an oncogenic pathway in HPV-associated cancer development and progression." @default.
• W2554986834 created "2016-11-30" @default.
• W2554986834 creator A5087773525 @default.
• W2554986834 date "2017-03-01" @default.
• W2554986834 modified "2023-09-27" @default.
• W2554986834 title "Activation of telomerase by HPVs" @default.
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• W2554986834 doi "https://doi.org/10.1016/j.virusres.2016.11.003" @default.
• W2554986834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27863966" @default.
• W2554986834 hasPublicationYear "2017" @default.
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