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• W2555000213 abstract "Abstract Dopamine is an important regulator of renal natriuresis and is critical for the adaptation of many animals to changing environmental salinity. However, the molecular mechanisms through which dopamine promotes this adaptation remain poorly understood. We studied the effects of dopamine on renal hypo-osmoregulation in the euryhaline fish Scatophagus argus ( S. argus ) during abrupt transfer from seawater (SW) to freshwater (FW). Following the transfer, serum dopamine concentration was decreased, and dopamine activated expression of the dopamine receptor 1 (designated SaDRD1 ) in the kidney, triggering the osmoregulatory signaling cascade. SaDRD1 protein is expressed in the renal proximal tubule cells in vivo , and is localized to the cell membrane of renal primary cells in vitro . Knockdown of SaDRD1 mRNA by siRNA significantly increased Na + /K + -ATPase (NKA) activity in cultured renal primary cells in vitro , suggesting that expression of SaDRD1 may oppose the activity of NKA. We demonstrate that exogenous dopamine enhances the response of NKA to hyposaline stress after transferring primary renal cells from isosmotic medium to hypoosmotic medium. Our results indicate that dopamine regulation via SaDRD1 ignited the renal dopaminergic system to balance the osmotic pressure through inhibiting NKA activity, providing a new perspective on the hyposaline adaptation of fish." @default.
• W2555000213 created "2016-11-30" @default.
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• W2555000213 date "2016-11-18" @default.
• W2555000213 modified "2023-09-27" @default.
• W2555000213 title "Dopamine regulates renal osmoregulation during hyposaline stress via DRD1 in the spotted scat (Scatophagus argus)" @default.
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• W2555000213 doi "https://doi.org/10.1038/srep37535" @default.
• W2555000213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5114590" @default.
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• W2555000213 hasPublicationYear "2016" @default.
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