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- W2555034233 endingPage "18" @default.
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- W2555034233 abstract "The dopamine transporter (DAT) is a plasma membrane phosphoprotein that actively translocates extracellular dopamine (DA) into presynaptic neurons. The transporter is the primary mechanism for control of DA levels and subsequent neurotransmission, and is the target for abused and therapeutic drugs that exert their effects by suppressing reuptake. The transport capacity of DAT is acutely regulated by signaling systems and drug exposure, providing neurons the ability to fine-tune DA clearance in response to specific conditions. Kinase pathways play major roles in these mechanisms, and this review summarizes the current status of DAT phosphorylation characteristics and the evidence linking transporter phosphorylation to control of reuptake and other functions. Greater understanding of these processes may aid in elucidation of their possible contributions to DA disease states and suggest specific phosphorylation sites as targets for therapeutic manipulation of reuptake." @default.
- W2555034233 created "2016-11-30" @default.
- W2555034233 creator A5016883013 @default.
- W2555034233 creator A5081734448 @default.
- W2555034233 creator A5089602272 @default.
- W2555034233 date "2017-10-01" @default.
- W2555034233 modified "2023-10-18" @default.
- W2555034233 title "Phosphorylation mechanisms in dopamine transporter regulation" @default.
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- W2555034233 doi "https://doi.org/10.1016/j.jchemneu.2016.10.004" @default.
- W2555034233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6705611" @default.
- W2555034233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28115272" @default.
- W2555034233 hasPublicationYear "2017" @default.
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