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• W2555035458 abstract "Putrescine, a polyamine present at high concentration in the mammalian brain, is reported putrescine can regulate a number of Ligand- gated ion channels including the 5HT receptor, Glutamate kainite receptor, GABA receptors and regulation of the NMDA receptor is complex which modulate convulsions. In this paper, we report on the biological activity of polyamine putrescine, which was tested as an anticonvulsant in model of chemically induced seizures and Maximal electroshock. The latency for development of convulsions and mortality rate was recorded in these models using mice. The result revealed that in MES- induced seizures model, putrescine (10, 30, 50, 100 mg/kg i.p.) decreased duration of tonic hind limb extension and percent mortality. Dose 100 mg/kg i.p. puterscine protected mice against isoniazid and PTZ induced tonic-clonic convulsions and decreased mortality. The results indicate that putrescine produces anticonvulsant like activity by conversion in GABA and modulate various neurotransmitter. In future, determination proconvulsion putrescine and level of GABA in brain and correlation with putrescine." @default.
• W2555035458 created "2016-11-30" @default.
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• W2555035458 date "2015-01-01" @default.
• W2555035458 modified "2023-09-27" @default.
• W2555035458 title "INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES (Int. J. of Pharm. Life Sci.) A Study on the Effect of Putrescine on MES and Chemical Induced Convulsions in Mice" @default.
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