FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555050401> ?p ?o ?g. }

• W2555050401 abstract "Purpose: Radiation-induced fibrosis (RIF) remains the most morbid complication of radiotherapy because of the absence of spontaneous regression and the difficulty of patient management. RIF treatment with combined pentoxifylline (PTX) and tocopherol (Vit E) was prompted by recent advances in cellular and molecular biology that have improved researchers’ understanding of radiation-induced late-injury mechanisms and by the excellent results from our previous human and animal studies. Patients and Methods: Forty-three patients (mean [6 SD] age, 59 6 10 years) presenting with 50 symptomatic RIF areas involving the skin and underlying tissues were treated from April 1995 to September 1997. Patients had had radiotherapy for head and neck or breast cancer a mean period of 8.5 6 6.5 years previously. RIF developed in the first year after irradiation and gradually worsened, without spontaneous regression. The mean measurable surface area of RIF ([S]) at the time of this study ([S0]) was 42 6 34 cm 2 . The initial Subjective Objective Medical management and Analytic (SOMA) injury evaluation score was 13.2 6 5.9 and included evidence of edema, plexitis, restricted movement, and local inflammatory signs. A combination of PTX (800 mg/d) and Vit E (1,000 IU/d) was administered orally for at least 6 months. Results: Treatment was well tolerated. All assessable injuries exhibited continuous clinical regression and functional improvement. Mean RIF surface area and SOMA scores improved significantly (P F .0001) at 3 months ([S3], 239%; [SOMA3], 222%), 6 months ([S6], 253%; [SOMA6], 235%), and 12 months ([S12], 266%; [SOMA12], 248%), and mean linear dimensions ([D]) diminished from the start of the study ([D0], 6.5 6 2.5 cm) to the end of treatment 12 months later ([D12], 4 6 2 cm). At the time of the treatment, we did not attempt to achieve the maximum effect, and the study was continued. Conclusion: The PTX-Vit E combination reversed human chronic radiotherapy damage and, because no other treatment is presently available for RIF, should be considered as a therapeutic measure. J Clin Oncol 17:3283-3290. r 1999 by American Society of Clinical Oncology." @default.
• W2555050401 created "2016-11-30" @default.
• W2555050401 creator A5052734844 @default.
• W2555050401 creator A5059469865 @default.
• W2555050401 creator A5086778028 @default.
• W2555050401 date "1999-01-01" @default.
• W2555050401 modified "2023-09-26" @default.
• W2555050401 title "Striking R egression o f C hronic R adiotherapy D amage i n a Clinical T rial o f C ombined P entoxifylline a nd T ocopherol" @default.
• W2555050401 cites W1968928657 @default.
• W2555050401 cites W1990933733 @default.
• W2555050401 cites W1991576017 @default.
• W2555050401 cites W1992421140 @default.
• W2555050401 cites W1994881755 @default.
• W2555050401 cites W1998538870 @default.
• W2555050401 cites W2010476323 @default.
• W2555050401 cites W2012070192 @default.
• W2555050401 cites W2012358031 @default.
• W2555050401 cites W2042628846 @default.
• W2555050401 cites W2046268684 @default.
• W2555050401 cites W2050795679 @default.
• W2555050401 cites W2057955197 @default.
• W2555050401 cites W2058011483 @default.
• W2555050401 cites W2061707351 @default.
• W2555050401 cites W2063256387 @default.
• W2555050401 cites W2074587267 @default.
• W2555050401 cites W2099227657 @default.
• W2555050401 cites W2114997949 @default.
• W2555050401 cites W2115418541 @default.
• W2555050401 cites W2158136101 @default.
• W2555050401 cites W2161438236 @default.
• W2555050401 cites W2211457406 @default.
• W2555050401 cites W2291489614 @default.
• W2555050401 cites W2409342462 @default.
• W2555050401 cites W611752577 @default.
• W2555050401 hasPublicationYear "1999" @default.
• W2555050401 type Work @default.
• W2555050401 sameAs 2555050401 @default.
• W2555050401 citedByCount "0" @default.
• W2555050401 crossrefType "journal-article" @default.
• W2555050401 hasAuthorship W2555050401A5052734844 @default.
• W2555050401 hasAuthorship W2555050401A5059469865 @default.
• W2555050401 hasAuthorship W2555050401A5086778028 @default.
• W2555050401 hasConcept C126322002 @default.
• W2555050401 hasConcept C141071460 @default.
• W2555050401 hasConcept C2780404050 @default.
• W2555050401 hasConcept C2780886150 @default.
• W2555050401 hasConcept C509974204 @default.
• W2555050401 hasConcept C71924100 @default.
• W2555050401 hasConcept C81182388 @default.
• W2555050401 hasConcept C90924648 @default.
• W2555050401 hasConceptScore W2555050401C126322002 @default.
• W2555050401 hasConceptScore W2555050401C141071460 @default.
• W2555050401 hasConceptScore W2555050401C2780404050 @default.
• W2555050401 hasConceptScore W2555050401C2780886150 @default.
• W2555050401 hasConceptScore W2555050401C509974204 @default.
• W2555050401 hasConceptScore W2555050401C71924100 @default.
• W2555050401 hasConceptScore W2555050401C81182388 @default.
• W2555050401 hasConceptScore W2555050401C90924648 @default.
• W2555050401 hasLocation W25550504011 @default.
• W2555050401 hasOpenAccess W2555050401 @default.
• W2555050401 hasPrimaryLocation W25550504011 @default.
• W2555050401 hasRelatedWork W1573315122 @default.
• W2555050401 hasRelatedWork W2011343179 @default.
• W2555050401 hasRelatedWork W2022629532 @default.
• W2555050401 hasRelatedWork W2027731772 @default.
• W2555050401 hasRelatedWork W2044450402 @default.
• W2555050401 hasRelatedWork W2092094151 @default.
• W2555050401 hasRelatedWork W2161047197 @default.
• W2555050401 hasRelatedWork W2348520686 @default.
• W2555050401 hasRelatedWork W2373562195 @default.
• W2555050401 hasRelatedWork W2415826130 @default.
• W2555050401 hasRelatedWork W2594749766 @default.
• W2555050401 hasRelatedWork W2756385022 @default.
• W2555050401 hasRelatedWork W3029422172 @default.
• W2555050401 hasRelatedWork W3030238553 @default.
• W2555050401 hasRelatedWork W3031244904 @default.
• W2555050401 hasRelatedWork W3031521618 @default.
• W2555050401 hasRelatedWork W3106995835 @default.
• W2555050401 hasRelatedWork W350285941 @default.
• W2555050401 hasRelatedWork W2551117799 @default.
• W2555050401 hasRelatedWork W2553938333 @default.
• W2555050401 isParatext "false" @default.
• W2555050401 isRetracted "false" @default.
• W2555050401 magId "2555050401" @default.
• W2555050401 workType "article" @default.