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- W2555072685 abstract "This review focuses on microRNAs (miRs) in cardiac surgery, where they are emerging as potential targets for therapeutic intervention as well as novel clinical biomarkers. Identification of the up/down-regulation of specific miRs in defined groups of cardiac surgery patients can lead to the development of novel strategies for targeted treatment in order to maximise therapeutic results and minimise acute, delayed or chronic complications. MiRs could also be involved in determining the outcome independently of complications, for example in relation to myocardial perfusion and fibrosis. Because of their relevance in disease, their known sequence and pharmacological properties, miRs are attractive candidates for therapeutic manipulation. Pharmacological inhibition of individual miRs can be achieved by modified antisense oligonucleotides, referred to as antimiRs, while miR replacement can be achieved by miR mimics to increase the level of a specific miR. MiR mimics can restore the function of a lost or down-regulated miR, while antimiRs can inhibit the levels of disease-driving or aberrantly expressed miRs, thus de-repressing the expression of mRNAs targeted by the miR. The main delivery methods for miR therapeutics involve lipid-based vehicles, viral systems, cationic polymers, and intravenous or local injection of an antagomiR. Local delivery is particularly desirable for miR therapeutics and options include the development of devices specific for local delivery, light-induced antimiR, and vesicle-encapsulated miRs serving as therapeutic delivery agents able to improve intracellular uptake. Here, we discuss the potential therapeutic use of miRNAs in the context of cardiac surgery." @default.
- W2555072685 created "2016-11-30" @default.
- W2555072685 creator A5014777117 @default.
- W2555072685 creator A5015199341 @default.
- W2555072685 creator A5018169854 @default.
- W2555072685 creator A5054764500 @default.
- W2555072685 creator A5061534140 @default.
- W2555072685 creator A5072730214 @default.
- W2555072685 date "2017-02-01" @default.
- W2555072685 modified "2023-09-23" @default.
- W2555072685 title "Modulating microRNAs in cardiac surgery patients: Novel therapeutic opportunities?" @default.
- W2555072685 cites W1146669903 @default.
- W2555072685 cites W122418684 @default.
- W2555072685 cites W1487286189 @default.
- W2555072685 cites W1512726137 @default.
- W2555072685 cites W1517919299 @default.
- W2555072685 cites W1557378337 @default.
- W2555072685 cites W1575075233 @default.
- W2555072685 cites W1595524810 @default.
- W2555072685 cites W1710900461 @default.
- W2555072685 cites W1758459338 @default.
- W2555072685 cites W1795045088 @default.
- W2555072685 cites W1813813055 @default.
- W2555072685 cites W1947221549 @default.
- W2555072685 cites W1966119039 @default.
- W2555072685 cites W1967686561 @default.
- W2555072685 cites W1968705313 @default.
- W2555072685 cites W1974770318 @default.
- W2555072685 cites W1975642357 @default.
- W2555072685 cites W1976228546 @default.
- W2555072685 cites W1977381537 @default.
- W2555072685 cites W1978976932 @default.
- W2555072685 cites W1979322303 @default.
- W2555072685 cites W1988194907 @default.
- W2555072685 cites W1989910375 @default.
- W2555072685 cites W1990311131 @default.
- W2555072685 cites W1991327393 @default.
- W2555072685 cites W1992389076 @default.
- W2555072685 cites W1996767888 @default.
- W2555072685 cites W1998135118 @default.
- W2555072685 cites W2005893093 @default.
- W2555072685 cites W2006247279 @default.
- W2555072685 cites W2006392505 @default.
- W2555072685 cites W2007582063 @default.
- W2555072685 cites W2007706112 @default.
- W2555072685 cites W2008297386 @default.
- W2555072685 cites W2011290576 @default.
- W2555072685 cites W2011566302 @default.
- W2555072685 cites W2012517517 @default.
- W2555072685 cites W2014955209 @default.
- W2555072685 cites W2015012480 @default.
- W2555072685 cites W2017358009 @default.
- W2555072685 cites W2021577982 @default.
- W2555072685 cites W2022380299 @default.
- W2555072685 cites W2024412145 @default.
- W2555072685 cites W2024896479 @default.
- W2555072685 cites W2026099724 @default.
- W2555072685 cites W2030712838 @default.
- W2555072685 cites W2033871452 @default.
- W2555072685 cites W2035068715 @default.
- W2555072685 cites W2035996281 @default.
- W2555072685 cites W2036921340 @default.
- W2555072685 cites W2036972432 @default.
- W2555072685 cites W2037413551 @default.
- W2555072685 cites W2039501347 @default.
- W2555072685 cites W2039820053 @default.
- W2555072685 cites W2042648990 @default.
- W2555072685 cites W2047493201 @default.
- W2555072685 cites W2048269289 @default.
- W2555072685 cites W2049597104 @default.
- W2555072685 cites W2050745993 @default.
- W2555072685 cites W2050750975 @default.
- W2555072685 cites W2052344110 @default.
- W2555072685 cites W2052558499 @default.
- W2555072685 cites W2053874045 @default.
- W2555072685 cites W2054174437 @default.
- W2555072685 cites W2054604628 @default.
- W2555072685 cites W2057724008 @default.
- W2555072685 cites W2063051111 @default.
- W2555072685 cites W2066907818 @default.
- W2555072685 cites W2067685971 @default.
- W2555072685 cites W2068707753 @default.
- W2555072685 cites W2069629141 @default.
- W2555072685 cites W2070960961 @default.
- W2555072685 cites W2072190764 @default.
- W2555072685 cites W2075690567 @default.
- W2555072685 cites W2077163089 @default.
- W2555072685 cites W2079761894 @default.
- W2555072685 cites W2080696342 @default.
- W2555072685 cites W2080942582 @default.
- W2555072685 cites W2083550820 @default.
- W2555072685 cites W2084740377 @default.
- W2555072685 cites W2085945726 @default.
- W2555072685 cites W2087103787 @default.
- W2555072685 cites W2087377443 @default.
- W2555072685 cites W2091919529 @default.
- W2555072685 cites W2092693006 @default.
- W2555072685 cites W2093478617 @default.