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• W2555099762 startingPage "741" @default.
• W2555099762 abstract "The aim of this study was to develop a new microemulsion formulation for topical application of poorly soluble drug named quercetin. In order to design suitable microemulsion system, the pseudo-ternary phase diagrams of microemulsion systems were constructed at different surfactant/co-surfactant ratios using tween 80 as surfactant, transcutol® P as a co-surfactant and oleic acid as an oil phase. Some physicochemical properties such as droplet size, density, refractive index, electrical conductivity, pH, surface tension, and viscosity of the microemulsion systems were measured at 298.15 K. The average hydrodynamic droplet size of the optimized microemulsions was obtained by dynamic light scattering method. Morphology assessment of the optimized quercetin-loaded microemulsion by transmission electron microscopy analysis indicated that the particles have the size of about 25 nm and spherical with narrow size distribution. Equilibrium solubility, in vitro drug release at a 24 h time period, release kinetic evaluation as well as ex vivo permeation and retention of quercetin-loaded microemulsions through rat skin has been investigated. The obtained results showed a slow release behavior without any transdermal delivery. Most of the formulations fitted best with zero-order kinetic model with a non-Fickian mechanisms. This study illustrated that the proposed QU-microemulsion has a good potential for use in sunscreen formulations." @default.
• W2555099762 created "2016-11-30" @default.
• W2555099762 creator A5035189409 @default.
• W2555099762 creator A5063109315 @default.
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• W2555099762 date "2016-12-09" @default.
• W2555099762 modified "2023-10-16" @default.
• W2555099762 title "Formulation, characterization, and <i>in vitro/ex vivo</i> evaluation of quercetin-loaded microemulsion for topical application" @default.
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• W2555099762 doi "https://doi.org/10.1080/10837450.2016.1263995" @default.
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• W2555099762 hasPublicationYear "2016" @default.
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