FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555130008> ?p ?o ?g. }

• W2555130008 endingPage "9" @default.
• W2555130008 startingPage "1" @default.
• W2555130008 abstract "Objectives . To investigate the protective effects of tropisetron on acetaminophen- (APAP-) induced liver injury in a mice model. Methods . C57BL/6 male mice were given tropisetron (0.3 to 10 mg/kg) 30 minutes before a hepatotoxic dose of acetaminophen (300 mg/kg) intraperitoneally. Twenty hours after APAP intoxication, sera alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, hepatic myeloperoxidase (MPO), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) activities, and liver histopathological changes were examined. The MAP kinases were also detected by western blotting. Results . Our results showed that tropisetron pretreatment significantly attenuated the acute elevations of the liver enzyme ALT level, hepatic MPO activity, and hepatocytes necrosis in a dose-dependent manner (0.3–10 mg/kg) in APAP-induced hepatotoxicity mice. Tropisetron (1 and 3 mg/kg) suppressed APAP-induced hepatic lipid peroxidation expression and alleviated GSH and SOD depletion. Administration of tropisetron also attenuated the phosphorylation of c-Jun-NH2-terminal protein kinase (JNK) and extracellular signal-regulated kinase (ERK) caused by APAP. Conclusion . Our data demonstrated that tropisetron’s hepatoprotective effect was in part correlated with the antioxidant, which were mediated via JNK and ERK pathways on acetaminophen-induced liver injury in mice." @default.
• W2555130008 created "2016-11-30" @default.
• W2555130008 creator A5002755579 @default.
• W2555130008 creator A5021851357 @default.
• W2555130008 creator A5050860612 @default.
• W2555130008 creator A5067279166 @default.
• W2555130008 creator A5091014280 @default.
• W2555130008 date "2016-01-01" @default.
• W2555130008 modified "2023-10-14" @default.
• W2555130008 title "Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways" @default.
• W2555130008 cites W1587116537 @default.
• W2555130008 cites W1840223240 @default.
• W2555130008 cites W1842932197 @default.
• W2555130008 cites W1925097974 @default.
• W2555130008 cites W1983493096 @default.
• W2555130008 cites W1991621876 @default.
• W2555130008 cites W1992543987 @default.
• W2555130008 cites W1996513478 @default.
• W2555130008 cites W1997037955 @default.
• W2555130008 cites W1997878364 @default.
• W2555130008 cites W1999452365 @default.
• W2555130008 cites W2003718301 @default.
• W2555130008 cites W2011910115 @default.
• W2555130008 cites W2015327415 @default.
• W2555130008 cites W2018944355 @default.
• W2555130008 cites W2021641296 @default.
• W2555130008 cites W2021760949 @default.
• W2555130008 cites W2038415365 @default.
• W2555130008 cites W2043738708 @default.
• W2555130008 cites W2047081614 @default.
• W2555130008 cites W2049155732 @default.
• W2555130008 cites W2054486269 @default.
• W2555130008 cites W2056309362 @default.
• W2555130008 cites W2057676577 @default.
• W2555130008 cites W2063566377 @default.
• W2555130008 cites W2066831888 @default.
• W2555130008 cites W2069139025 @default.
• W2555130008 cites W2079118329 @default.
• W2555130008 cites W2082615196 @default.
• W2555130008 cites W2084178759 @default.
• W2555130008 cites W2084441247 @default.
• W2555130008 cites W2094762772 @default.
• W2555130008 cites W2100012786 @default.
• W2555130008 cites W2102834219 @default.
• W2555130008 cites W2103891066 @default.
• W2555130008 cites W2108295799 @default.
• W2555130008 cites W2130326256 @default.
• W2555130008 cites W2136956219 @default.
• W2555130008 cites W2160775206 @default.
• W2555130008 cites W2161817746 @default.
• W2555130008 cites W2274688339 @default.
• W2555130008 cites W2312664362 @default.
• W2555130008 cites W2410897102 @default.
• W2555130008 doi "https://doi.org/10.1155/2016/1952947" @default.
• W2555130008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5116490" @default.
• W2555130008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27891510" @default.
• W2555130008 hasPublicationYear "2016" @default.
• W2555130008 type Work @default.
• W2555130008 sameAs 2555130008 @default.
• W2555130008 citedByCount "15" @default.
• W2555130008 countsByYear W25551300082017 @default.
• W2555130008 countsByYear W25551300082018 @default.
• W2555130008 countsByYear W25551300082019 @default.
• W2555130008 countsByYear W25551300082020 @default.
• W2555130008 crossrefType "journal-article" @default.
• W2555130008 hasAuthorship W2555130008A5002755579 @default.
• W2555130008 hasAuthorship W2555130008A5021851357 @default.
• W2555130008 hasAuthorship W2555130008A5050860612 @default.
• W2555130008 hasAuthorship W2555130008A5067279166 @default.
• W2555130008 hasAuthorship W2555130008A5091014280 @default.
• W2555130008 hasBestOaLocation W25551300081 @default.
• W2555130008 hasConcept C126322002 @default.
• W2555130008 hasConcept C170493617 @default.
• W2555130008 hasConcept C181199279 @default.
• W2555130008 hasConcept C184235292 @default.
• W2555130008 hasConcept C185592680 @default.
• W2555130008 hasConcept C203565725 @default.
• W2555130008 hasConcept C2775838275 @default.
• W2555130008 hasConcept C2775864247 @default.
• W2555130008 hasConcept C2776151105 @default.
• W2555130008 hasConcept C2776514860 @default.
• W2555130008 hasConcept C2776637226 @default.
• W2555130008 hasConcept C2776914184 @default.
• W2555130008 hasConcept C2778144076 @default.
• W2555130008 hasConcept C2778401633 @default.
• W2555130008 hasConcept C2778722691 @default.
• W2555130008 hasConcept C2780829032 @default.
• W2555130008 hasConcept C538909803 @default.
• W2555130008 hasConcept C55493867 @default.
• W2555130008 hasConcept C57074206 @default.
• W2555130008 hasConcept C71924100 @default.
• W2555130008 hasConcept C98274493 @default.
• W2555130008 hasConceptScore W2555130008C126322002 @default.
• W2555130008 hasConceptScore W2555130008C170493617 @default.
• W2555130008 hasConceptScore W2555130008C181199279 @default.
• W2555130008 hasConceptScore W2555130008C184235292 @default.
• W2555130008 hasConceptScore W2555130008C185592680 @default.
• W2555130008 hasConceptScore W2555130008C203565725 @default.

• next