Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555135963> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2555135963 abstract "Background Ankylosing spondylitis (AS) is not only characterized by excessive bone formation, but also by excessive bone loss which may lead to low bone mineral density (BMD). So far, little is known about the effect of treatment with bisphosphonates on BMD in patients with AS. Objectives To evaluate the effect of bisphosphonates in combination with calcium/vitamin D supplements on BMD over 2 years in patients with AS stratified for the use of TNF-α inhibitors. Methods Patients from the Groningen Leeuwarden AS (GLAS) cohort, fulfilling the modified New York criteria for AS, who were treated with bisphosphonates and had 2-year follow-up BMD measurements available were included. All patients were treated with bisphosphonates in combination with calcium and/or vitamin D supplements. Alendronate (70 mg/week) and risedronate (35 mg/week) were used most frequently. BMD of the lumbar spine (anterior-posterior projection at L1-L4) and hip (total proximal femur) were measured using DXA. Wilcoxon-signed rank test was used to compare BMD scores at first visit and after 2 years. Analyses were stratified for the use of TNF-α inhibitors. Results In total, 28 patients were included; 68% were male, 82% HLA-B27+, mean age was 53 ± 14 years, median symptom duration 20 years (range 1–60), and mean BASDAI 5.1±2.5. Fifteen patients (54%) started treatment with bisphosphonates before inclusion in the GLAS cohort (median 3.1 years). Most patients (86%) used bisphosphonates during the entire 2-year follow-up within GLAS. Overall, lumbar spine BMD increased significantly from median Z-score of -0.8 at first visit to -0.3 after 2 years of treatment with bisphosphonates within the GLAS cohort. Hip BMD increased significantly from -1.1 at first visit to -0.9 after 2 years. In the 10 patients not using TNF-α inhibitors, only lumbar spine BMD increased significantly after 2 years of treatment. In the 14 patients starting TNF-α inhibitors, lumbar spine and hip BMD increased significantly after 2 years. The remaining 4 patients already used TNF-α inhibitors (Table 1). Comparable results were found for BMD T-scores. Conclusions In our observational cohort study, lumbar spine BMD improved significantly after 2 years of follow-up in all AS patients treated with bisphosphonates. This improvement was most pronounced in patients starting TNF-α inhibitors. Hip BMD only improved significantly in patients also starting TNF-α inhibitors. Acknowledgement The GLAS cohort was supported by an unrestricted grant from Pfizer. Pfizer had no role in the design, conduct, interpretation, or publication of this study. Disclosure of Interest S. Arends Grant/research support from: Pfizer, J. Veneberg: None declared, F. Wink Consultant for: Abbvie, R. Bos Grant/research support from: Pfizer, E. Brouwer Grant/research support from: Pfizer, E. van der Veer: None declared, H. Bootsma: None declared, E. van Roon: None declared, F. Maas: None declared, A. Spoorenberg Grant/research support from: Abbvie, Pfizer, UCB, Consultant for: Abbvie, Pfizer, MSD, UCB, Novartis" @default.
- W2555135963 created "2016-11-30" @default.
- W2555135963 creator A5005994370 @default.
- W2555135963 creator A5028106660 @default.
- W2555135963 creator A5032738880 @default.
- W2555135963 creator A5035269803 @default.
- W2555135963 creator A5044334265 @default.
- W2555135963 creator A5045187079 @default.
- W2555135963 creator A5046964429 @default.
- W2555135963 creator A5052491189 @default.
- W2555135963 creator A5065705574 @default.
- W2555135963 creator A5079680665 @default.
- W2555135963 date "2016-06-01" @default.
- W2555135963 modified "2023-09-27" @default.
- W2555135963 title "SAT0418 The Effect of Bisphosphonates on Bone Mineral Density in Patients with Ankylosing Spondylitis in Daily Clinical Practice" @default.
- W2555135963 doi "https://doi.org/10.1136/annrheumdis-2016-eular.3897" @default.
- W2555135963 hasPublicationYear "2016" @default.
- W2555135963 type Work @default.
- W2555135963 sameAs 2555135963 @default.
- W2555135963 citedByCount "0" @default.
- W2555135963 crossrefType "journal-article" @default.
- W2555135963 hasAuthorship W2555135963A5005994370 @default.
- W2555135963 hasAuthorship W2555135963A5028106660 @default.
- W2555135963 hasAuthorship W2555135963A5032738880 @default.
- W2555135963 hasAuthorship W2555135963A5035269803 @default.
- W2555135963 hasAuthorship W2555135963A5044334265 @default.
- W2555135963 hasAuthorship W2555135963A5045187079 @default.
- W2555135963 hasAuthorship W2555135963A5046964429 @default.
- W2555135963 hasAuthorship W2555135963A5052491189 @default.
- W2555135963 hasAuthorship W2555135963A5065705574 @default.
- W2555135963 hasAuthorship W2555135963A5079680665 @default.
- W2555135963 hasConcept C124490489 @default.
- W2555135963 hasConcept C126322002 @default.
- W2555135963 hasConcept C126894567 @default.
- W2555135963 hasConcept C141071460 @default.
- W2555135963 hasConcept C2776260265 @default.
- W2555135963 hasConcept C2776541429 @default.
- W2555135963 hasConcept C2776886416 @default.
- W2555135963 hasConcept C2777083390 @default.
- W2555135963 hasConcept C2777402515 @default.
- W2555135963 hasConcept C2777453003 @default.
- W2555135963 hasConcept C2777575956 @default.
- W2555135963 hasConcept C71924100 @default.
- W2555135963 hasConcept C72563966 @default.
- W2555135963 hasConceptScore W2555135963C124490489 @default.
- W2555135963 hasConceptScore W2555135963C126322002 @default.
- W2555135963 hasConceptScore W2555135963C126894567 @default.
- W2555135963 hasConceptScore W2555135963C141071460 @default.
- W2555135963 hasConceptScore W2555135963C2776260265 @default.
- W2555135963 hasConceptScore W2555135963C2776541429 @default.
- W2555135963 hasConceptScore W2555135963C2776886416 @default.
- W2555135963 hasConceptScore W2555135963C2777083390 @default.
- W2555135963 hasConceptScore W2555135963C2777402515 @default.
- W2555135963 hasConceptScore W2555135963C2777453003 @default.
- W2555135963 hasConceptScore W2555135963C2777575956 @default.
- W2555135963 hasConceptScore W2555135963C71924100 @default.
- W2555135963 hasConceptScore W2555135963C72563966 @default.
- W2555135963 hasLocation W25551359631 @default.
- W2555135963 hasOpenAccess W2555135963 @default.
- W2555135963 hasPrimaryLocation W25551359631 @default.
- W2555135963 hasRelatedWork W1977508555 @default.
- W2555135963 hasRelatedWork W2046428498 @default.
- W2555135963 hasRelatedWork W2060242325 @default.
- W2555135963 hasRelatedWork W2067007860 @default.
- W2555135963 hasRelatedWork W2085559668 @default.
- W2555135963 hasRelatedWork W2096303371 @default.
- W2555135963 hasRelatedWork W2096921861 @default.
- W2555135963 hasRelatedWork W2134910437 @default.
- W2555135963 hasRelatedWork W2345278582 @default.
- W2555135963 hasRelatedWork W2523651260 @default.
- W2555135963 hasRelatedWork W2580477598 @default.
- W2555135963 hasRelatedWork W2588499028 @default.
- W2555135963 hasRelatedWork W2589352961 @default.
- W2555135963 hasRelatedWork W2809901902 @default.
- W2555135963 hasRelatedWork W2910035498 @default.
- W2555135963 hasRelatedWork W2978630384 @default.
- W2555135963 hasRelatedWork W3097676380 @default.
- W2555135963 hasRelatedWork W3132522413 @default.
- W2555135963 hasRelatedWork W3138944102 @default.
- W2555135963 hasRelatedWork W1887258919 @default.
- W2555135963 isParatext "false" @default.
- W2555135963 isRetracted "false" @default.
- W2555135963 magId "2555135963" @default.
- W2555135963 workType "article" @default.