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- W2555141845 endingPage "80" @default.
- W2555141845 startingPage "66" @default.
- W2555141845 abstract "Current therapies to treat autoimmune diseases often result in side effects such as nonspecific immunosuppression. Therapies that can induce antigen-specific immune tolerance provide an opportunity to reverse autoimmunity and mitigate the risks associated with global immunosuppression. In an effort to induce antigen-specific immune tolerance, co-administration of immunomodulators with autoantigens has been investigated in an effort to reprogram autoimmunity. To date, identifying immunomodulators that may skew the antigen-specific immune response has been ad hoc at best. To address this need, we utilized splenocytes obtained from mice with experimental autoimmune encephalomyelitis (EAE) in order to determine if certain immunomodulators may induce markers of immune tolerance following antigen rechallenge. Of the immunomodulatory compounds investigated, only dexamethasone modified the antigen-specific immune response by skewing the cytokine response and decreasing T-cell populations at a concentration corresponding to a relevant in vivo dose. Thus, antigen-educated EAE splenocytes provide an ex vivo screen for investigating compounds capable of skewing the antigen-specific immune response, and this approach could be extrapolated to antigen-educated cells from other diseases or human tissues." @default.
- W2555141845 created "2016-11-30" @default.
- W2555141845 creator A5006935364 @default.
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- W2555141845 creator A5032029853 @default.
- W2555141845 creator A5074470140 @default.
- W2555141845 creator A5090889599 @default.
- W2555141845 date "2016-12-07" @default.
- W2555141845 modified "2023-09-26" @default.
- W2555141845 title "Screening Immunomodulators To Skew the Antigen-Specific Autoimmune Response" @default.
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