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- W2555142691 abstract "This issue of AJHP is a theme issue on precision medicine, focusing on the use of pharmacogenetics in the clinical setting. The articles included provide substantial insight on how and why pharmacogenetics might and can be implemented in the clinical setting. In the past three to five years, the number of institutions undertaking such implementations has steadily increased, so concrete examples are now available. The opportunity that clinical pharmacogenetics presents for pharmacists is substantial, and ASHP is to be commended for taking a leading role to help advance the profession’s stake in this important aspect of healthcare. The term pharmacogenetics was first coined in the 1950s, with the discoveries of genetic variations in plasma cholinesterase activity and their effect on patients’ response to succinylcholine, genetic variability in the genes encoding N-acetyltransferase that contributed to toxic responses to isoniazid, and the presence of glucose-6-phosphate dehydrogenase deficiency among patients experiencing hemolytic anemia after receiving primaquine.1 Sixty years have passed since there was an appreciation for inherited differences in drug responses, based on similarities observed within families and differences between specific populations (e.g., those of European versus Asian versus African ancestry). However, it was not until the 1990s that molecular tools became available to more readily define the genetic basis for such differences. At the turn of the 21st century, advances in genomic technologies created the opportunity to study multiple genes, and pharmacogenomics came into vogue. Distinct definitions for pharmacogenetics and pharmacogenomics can be argued, but these terms are often treated as synonyms. I use the term pharmacogenetics because, in the clinical setting, attention is typically focused on one or two genes to guide a specific clinical decision." @default.
- W2555142691 created "2016-11-30" @default.
- W2555142691 creator A5088669682 @default.
- W2555142691 date "2016-12-01" @default.
- W2555142691 modified "2023-09-28" @default.
- W2555142691 title "Pharmacists should jump onto the clinical pharmacogenetics train" @default.
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- W2555142691 doi "https://doi.org/10.2146/ajhp160046" @default.
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