Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555142972> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2555142972 endingPage "62" @default.
- W2555142972 startingPage "58" @default.
- W2555142972 abstract "Equine herpesvirus type 1 (EHV-1) is responsible for respiratory disorders, abortion and myeloencephalopathy (EHM) in horses. Two pathotypes of EHV-1 strains are circulating in the field: neurovirulent (N) and non-neurovirulent (NN). For both strains, CD172a+ monocytic cells are one of the main carrier cells of EHV-1 during primary infection, allowing the virus to invade the horse’s body. Recently, we showed that EHV-1 NN strains showed a restricted and delayed replication in CD172a+ cells. Here we characterize the in vitro replication kinetics of two EHV-1 N strains in CD172a+ cells and investigate if the replication of these strains is similarly silenced as shown for EHV-1 NN strains. We found that EHV-1 N replication was restricted to 7–8% in CD172a+ cells compared to 100% in control RK-13 cells. EHV-1 N replication was not delayed in CD172a+ cells but virus production was significant lower (103.0 TCID50/105 inoculated cells) than in RK-13 cells (108.5 TCID50/105 inoculated cells). Approximately 0.04% of CD172a+ cells produced and transmitted infectious EHV-1 to neighbour cells compared to 65% of RK-13 cells. Unlike what we observed for the NN strain, pretreatment of CD172a+ cells with histone deacetylases inhibitors (HDACi) did not influence the replication of EHV-1 N strains in these cells. Overall, these results show that the EHV-1 replication of N strains in CD172a+ cells differs from that observed for NN strains, which may contribute to their different pathogeneses in vivo." @default.
- W2555142972 created "2016-11-30" @default.
- W2555142972 creator A5019436714 @default.
- W2555142972 creator A5056081975 @default.
- W2555142972 creator A5062878756 @default.
- W2555142972 creator A5076542288 @default.
- W2555142972 creator A5088924293 @default.
- W2555142972 date "2017-02-01" @default.
- W2555142972 modified "2023-10-16" @default.
- W2555142972 title "Replication of neurovirulent equine herpesvirus type 1 (EHV-1) in CD172a+ monocytic cells" @default.
- W2555142972 cites W1645406539 @default.
- W2555142972 cites W1992373534 @default.
- W2555142972 cites W2018992544 @default.
- W2555142972 cites W2063979108 @default.
- W2555142972 cites W2072085292 @default.
- W2555142972 cites W2083964202 @default.
- W2555142972 cites W2089970346 @default.
- W2555142972 cites W2105925537 @default.
- W2555142972 cites W2129419052 @default.
- W2555142972 cites W2155478615 @default.
- W2555142972 cites W2167022679 @default.
- W2555142972 cites W2414541769 @default.
- W2555142972 doi "https://doi.org/10.1016/j.cimid.2016.11.006" @default.
- W2555142972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28131380" @default.
- W2555142972 hasPublicationYear "2017" @default.
- W2555142972 type Work @default.
- W2555142972 sameAs 2555142972 @default.
- W2555142972 citedByCount "7" @default.
- W2555142972 countsByYear W25551429722019 @default.
- W2555142972 countsByYear W25551429722020 @default.
- W2555142972 countsByYear W25551429722021 @default.
- W2555142972 countsByYear W25551429722022 @default.
- W2555142972 crossrefType "journal-article" @default.
- W2555142972 hasAuthorship W2555142972A5019436714 @default.
- W2555142972 hasAuthorship W2555142972A5056081975 @default.
- W2555142972 hasAuthorship W2555142972A5062878756 @default.
- W2555142972 hasAuthorship W2555142972A5076542288 @default.
- W2555142972 hasAuthorship W2555142972A5088924293 @default.
- W2555142972 hasConcept C140704245 @default.
- W2555142972 hasConcept C159047783 @default.
- W2555142972 hasConcept C202751555 @default.
- W2555142972 hasConcept C207001950 @default.
- W2555142972 hasConcept C2522874641 @default.
- W2555142972 hasConcept C2775976905 @default.
- W2555142972 hasConcept C2776409557 @default.
- W2555142972 hasConcept C2780727368 @default.
- W2555142972 hasConcept C54355233 @default.
- W2555142972 hasConcept C81885089 @default.
- W2555142972 hasConcept C86803240 @default.
- W2555142972 hasConcept C89423630 @default.
- W2555142972 hasConceptScore W2555142972C140704245 @default.
- W2555142972 hasConceptScore W2555142972C159047783 @default.
- W2555142972 hasConceptScore W2555142972C202751555 @default.
- W2555142972 hasConceptScore W2555142972C207001950 @default.
- W2555142972 hasConceptScore W2555142972C2522874641 @default.
- W2555142972 hasConceptScore W2555142972C2775976905 @default.
- W2555142972 hasConceptScore W2555142972C2776409557 @default.
- W2555142972 hasConceptScore W2555142972C2780727368 @default.
- W2555142972 hasConceptScore W2555142972C54355233 @default.
- W2555142972 hasConceptScore W2555142972C81885089 @default.
- W2555142972 hasConceptScore W2555142972C86803240 @default.
- W2555142972 hasConceptScore W2555142972C89423630 @default.
- W2555142972 hasLocation W25551429721 @default.
- W2555142972 hasLocation W25551429722 @default.
- W2555142972 hasOpenAccess W2555142972 @default.
- W2555142972 hasPrimaryLocation W25551429721 @default.
- W2555142972 hasRelatedWork W1608862421 @default.
- W2555142972 hasRelatedWork W1825162875 @default.
- W2555142972 hasRelatedWork W1990141933 @default.
- W2555142972 hasRelatedWork W1991126365 @default.
- W2555142972 hasRelatedWork W2020692772 @default.
- W2555142972 hasRelatedWork W2021255975 @default.
- W2555142972 hasRelatedWork W2046533420 @default.
- W2555142972 hasRelatedWork W2406270448 @default.
- W2555142972 hasRelatedWork W2464301138 @default.
- W2555142972 hasRelatedWork W3165029026 @default.
- W2555142972 hasVolume "50" @default.
- W2555142972 isParatext "false" @default.
- W2555142972 isRetracted "false" @default.
- W2555142972 magId "2555142972" @default.
- W2555142972 workType "article" @default.