FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555145868> ?p ?o ?g. }

• W2555145868 abstract "The twister ribozyme motif has been identified by bioinformatic means very recently. Currently, four crystal structures with ordered active sites together with a series of chemical and biochemical data provide insights into how this RNA accomplishes its efficient self-cleavage. Of particular interest for a mechanistic proposal are structural distinctions observed in the active sites that concern the conformation of the U-A cleavage site dinucleotide (in-line alignment of the attacking 2'-O nucleophile to the to-be-cleaved PO5' bond versus suboptimal alignments) as well as the presence/absence of Mg2+ ions at the scissile phosphate. All structures support the notion that an active site guanine and the conserved adenine at the cleavage site are important contributors to cleavage chemistry, likely being involved in general acid base catalysis. Evidence for innersphere coordination of a Mg2+ ion to the pro-S nonbridging oxygen of the scissile phosphate stems from two of the four crystal structures. Together with the finding of thio/rescue effects for phosphorothioate substrates, this suggests the participation of divalent ions in the overall catalytic strategy employed by twister ribozymes. In this context, it is notable that twister retains wild-type activity when the phylogenetically conserved stem P1 is deleted, able to cleave a single nucleotide only. WIREs RNA 2017, 8:e1402. doi: 10.1002/wrna.1402 For further resources related to this article, please visit the WIREs website." @default.
• W2555145868 created "2016-11-30" @default.
• W2555145868 creator A5042662232 @default.
• W2555145868 creator A5058574119 @default.
• W2555145868 date "2016-11-14" @default.
• W2555145868 modified "2023-10-17" @default.
• W2555145868 title "Unwinding the twister ribozyme: from structure to mechanism" @default.
• W2555145868 cites W1502906266 @default.
• W2555145868 cites W1585990551 @default.
• W2555145868 cites W159629311 @default.
• W2555145868 cites W1642023497 @default.
• W2555145868 cites W1862261356 @default.
• W2555145868 cites W1881326155 @default.
• W2555145868 cites W1891814836 @default.
• W2555145868 cites W1964607399 @default.
• W2555145868 cites W1965464174 @default.
• W2555145868 cites W1965716098 @default.
• W2555145868 cites W1967565706 @default.
• W2555145868 cites W1971589546 @default.
• W2555145868 cites W1972519138 @default.
• W2555145868 cites W1980410097 @default.
• W2555145868 cites W1981167137 @default.
• W2555145868 cites W1983636237 @default.
• W2555145868 cites W1983744996 @default.
• W2555145868 cites W1993039491 @default.
• W2555145868 cites W1999404678 @default.
• W2555145868 cites W2003201962 @default.
• W2555145868 cites W2008797142 @default.
• W2555145868 cites W2008820030 @default.
• W2555145868 cites W2011078969 @default.
• W2555145868 cites W2019039775 @default.
• W2555145868 cites W2039917092 @default.
• W2555145868 cites W2042804956 @default.
• W2555145868 cites W2043637185 @default.
• W2555145868 cites W2044067798 @default.
• W2555145868 cites W2044608322 @default.
• W2555145868 cites W2047066335 @default.
• W2555145868 cites W2056442009 @default.
• W2555145868 cites W2063336974 @default.
• W2555145868 cites W2069348762 @default.
• W2555145868 cites W2069528284 @default.
• W2555145868 cites W2072245156 @default.
• W2555145868 cites W2074312400 @default.
• W2555145868 cites W2081030386 @default.
• W2555145868 cites W2081125994 @default.
• W2555145868 cites W2084705960 @default.
• W2555145868 cites W2084943154 @default.
• W2555145868 cites W2085954575 @default.
• W2555145868 cites W2090624684 @default.
• W2555145868 cites W2092525178 @default.
• W2555145868 cites W2104095017 @default.
• W2555145868 cites W2105638515 @default.
• W2555145868 cites W2106478835 @default.
• W2555145868 cites W2114934186 @default.
• W2555145868 cites W2115729502 @default.
• W2555145868 cites W2130112867 @default.
• W2555145868 cites W2131789928 @default.
• W2555145868 cites W2137844204 @default.
• W2555145868 cites W2141652369 @default.
• W2555145868 cites W2141779505 @default.
• W2555145868 cites W2143590611 @default.
• W2555145868 cites W2144759995 @default.
• W2555145868 cites W2153461732 @default.
• W2555145868 cites W2159946246 @default.
• W2555145868 cites W2160498409 @default.
• W2555145868 cites W2161329577 @default.
• W2555145868 cites W2162029177 @default.
• W2555145868 cites W2167470206 @default.
• W2555145868 cites W2195337028 @default.
• W2555145868 cites W2220550654 @default.
• W2555145868 cites W2266391584 @default.
• W2555145868 cites W2275900200 @default.
• W2555145868 cites W2289773886 @default.
• W2555145868 cites W2309582172 @default.
• W2555145868 cites W2322130305 @default.
• W2555145868 cites W2327735743 @default.
• W2555145868 cites W2346647512 @default.
• W2555145868 cites W2434320854 @default.
• W2555145868 cites W2468944904 @default.
• W2555145868 cites W2523935508 @default.
• W2555145868 cites W4317933505 @default.
• W2555145868 doi "https://doi.org/10.1002/wrna.1402" @default.
• W2555145868 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5408937" @default.
• W2555145868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27863022" @default.
• W2555145868 hasPublicationYear "2016" @default.
• W2555145868 type Work @default.
• W2555145868 sameAs 2555145868 @default.
• W2555145868 citedByCount "33" @default.
• W2555145868 countsByYear W25551458682016 @default.
• W2555145868 countsByYear W25551458682017 @default.
• W2555145868 countsByYear W25551458682018 @default.
• W2555145868 countsByYear W25551458682019 @default.
• W2555145868 countsByYear W25551458682020 @default.
• W2555145868 countsByYear W25551458682021 @default.
• W2555145868 countsByYear W25551458682022 @default.
• W2555145868 crossrefType "journal-article" @default.
• W2555145868 hasAuthorship W2555145868A5042662232 @default.
• W2555145868 hasAuthorship W2555145868A5058574119 @default.
• W2555145868 hasBestOaLocation W25551458681 @default.
• W2555145868 hasConcept C104317684 @default.

• next