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- W2555169258 abstract "Background: Cervical cancer is one of the most important cancers worldwide with a high incident and mortality rate. Even though many sexually active women get infected with human papillomavirus (HPV), only a small fraction of them progress to cervical cancer suggesting the important roles of the additional risk factors in development of the disease including host genetic factors and other infections such as HSV-2. Since cellular apoptosis plays a crucial role in controlling the spread of virus-infections in cells, functional variations in cell death pathway genes might alter the apoptotic mechanism, thereby influencing its ability to clear virus-infections. Functional polymorphisms in FasR (-1377G>A and -670A>G), FasL (-844T>C) and CASP8 (-652 6N ins/del) genes are all know to alter the mechanism of apoptosis by modifying the level of expression of their correspondent proteins. These polymorphisms have been investigated in cervical cancer by different groups including our lab previously." @default.
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- W2555169258 date "2014-08-26" @default.
- W2555169258 modified "2023-09-28" @default.
- W2555169258 title "The combined effects of the functional variants in cell death pathway genes influence herpes simplex virus type-2 infection but not cervical cancer" @default.
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