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- W2555192783 abstract "Background: The pulmonary artery to aorta ratio (PA:A) is often used as a proxy for pulmonary hypertension. In smokers with COPD, PA:A > 1 has also been associated with an increased risk of severe exacerbations of COPD (i.e. hospitalizations). The aim of this study was to investigate the association between PA:A and mortality in the general population and in patients with COPD. Methods: In 2,197 participants from the population-based Rotterdam Study (mean age ± standard deviation (SD) 69.7 ± 6.7, 51.3% females), PA:A was measured using a cardiac CT scan performed between 2003 and 2006 . PA:A was defined as the ratio between the diameter of the pulmonary artery and the aorta. Multivariable Cox regression models (adjusted for age, sex, weight, smoking, and diabetes) were used to investigate the relationship between PA:A and the risk of mortality. Results: We found that PA:A was associated with a higher risk of mortality in the general population [Hazard Ratio (HR) for mortality per SD increase in PA:A: 1.11 (95% CI: 1.01-1.23)]. The association was more pronounced in participants with moderate to severe COPD (n=107) [HR adj : 1.62 (95% CI: 1.05-2.49)]. Investigating PA:A quartiles in moderate to severe COPD cases, the highest quartile of the PA:A showed the lowest survival using the lowest quartile as reference [HR adj 10.60 (95% CI: 1.83-61.37)]. Conclusion: PA:A is associated with increased mortality in the general population and in subjects with moderate to severe COPD." @default.
- W2555192783 created "2016-11-30" @default.
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- W2555192783 date "2016-09-01" @default.
- W2555192783 modified "2023-09-27" @default.
- W2555192783 title "Pulmonary artery to aorta ratio and mortality risk in the general population: The Rotterdam study" @default.
- W2555192783 doi "https://doi.org/10.1183/13993003.congress-2016.pa741" @default.
- W2555192783 hasPublicationYear "2016" @default.
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