Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555230831> ?p ?o ?g. }
- W2555230831 abstract "The SLC22 family comprises organic cation transporters (OCTs), zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). These transporters contain 12 predicted a-helical transmem- brane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways: (1) as uniporters that mediate facilitated diffusion in either direction (OCTs), (2) as anion exchangers (OAT1, OAT3 and URAT1), and (3) as Na + /l-carnitine cotransporter (OCTN2). They participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver and/or kidney, and perform homeostatic functions in brain and heart. The endogenous substrates include monoamine neurotransmitters, choline, l-carnitine, a- ketoglutarate, cAMP, cGMP, prostaglandins, and urate. Defect mutations of transporters of the SLC22 family may cause specific diseases such as primary systemic carni- tine deficiency or idiopathic renal hypouricemia or change drug absorption or excretion." @default.
- W2555230831 created "2016-11-30" @default.
- W2555230831 creator A5002253759 @default.
- W2555230831 creator A5064438527 @default.
- W2555230831 date "2004-01-01" @default.
- W2555230831 modified "2023-09-27" @default.
- W2555230831 title "The A BC o f S olute C arriers" @default.
- W2555230831 cites W1493374490 @default.
- W2555230831 cites W1588849194 @default.
- W2555230831 cites W1786528573 @default.
- W2555230831 cites W1844834026 @default.
- W2555230831 cites W1859440284 @default.
- W2555230831 cites W1950961128 @default.
- W2555230831 cites W1965477067 @default.
- W2555230831 cites W1977244805 @default.
- W2555230831 cites W1978521624 @default.
- W2555230831 cites W1980984502 @default.
- W2555230831 cites W1983786078 @default.
- W2555230831 cites W1986731020 @default.
- W2555230831 cites W1986732006 @default.
- W2555230831 cites W1996402420 @default.
- W2555230831 cites W1997038641 @default.
- W2555230831 cites W1998095254 @default.
- W2555230831 cites W1998206026 @default.
- W2555230831 cites W2005683036 @default.
- W2555230831 cites W2014775626 @default.
- W2555230831 cites W2025057200 @default.
- W2555230831 cites W2027579967 @default.
- W2555230831 cites W2033670502 @default.
- W2555230831 cites W2033674260 @default.
- W2555230831 cites W2035090455 @default.
- W2555230831 cites W2048541050 @default.
- W2555230831 cites W2058859643 @default.
- W2555230831 cites W2060612591 @default.
- W2555230831 cites W2062734451 @default.
- W2555230831 cites W2063793074 @default.
- W2555230831 cites W2067650742 @default.
- W2555230831 cites W2072938074 @default.
- W2555230831 cites W2073048087 @default.
- W2555230831 cites W2074813983 @default.
- W2555230831 cites W2075725919 @default.
- W2555230831 cites W2081750550 @default.
- W2555230831 cites W2082188851 @default.
- W2555230831 cites W2084483849 @default.
- W2555230831 cites W2085047894 @default.
- W2555230831 cites W2093525797 @default.
- W2555230831 cites W2096136187 @default.
- W2555230831 cites W2096169020 @default.
- W2555230831 cites W2097785193 @default.
- W2555230831 cites W2098924785 @default.
- W2555230831 cites W2101403210 @default.
- W2555230831 cites W2103213593 @default.
- W2555230831 cites W2104587909 @default.
- W2555230831 cites W2111575755 @default.
- W2555230831 cites W2115178828 @default.
- W2555230831 cites W2124498834 @default.
- W2555230831 cites W2134032476 @default.
- W2555230831 cites W2135290874 @default.
- W2555230831 cites W2136763277 @default.
- W2555230831 cites W2145869500 @default.
- W2555230831 cites W2149786401 @default.
- W2555230831 cites W2152702915 @default.
- W2555230831 cites W2154270498 @default.
- W2555230831 cites W2156244027 @default.
- W2555230831 cites W2157721092 @default.
- W2555230831 cites W2160034626 @default.
- W2555230831 cites W2161310946 @default.
- W2555230831 cites W2179797938 @default.
- W2555230831 cites W2187984788 @default.
- W2555230831 cites W2264001376 @default.
- W2555230831 cites W2274797767 @default.
- W2555230831 hasPublicationYear "2004" @default.
- W2555230831 type Work @default.
- W2555230831 sameAs 2555230831 @default.
- W2555230831 citedByCount "0" @default.
- W2555230831 crossrefType "journal-article" @default.
- W2555230831 hasAuthorship W2555230831A5002253759 @default.
- W2555230831 hasAuthorship W2555230831A5064438527 @default.
- W2555230831 hasConcept C104317684 @default.
- W2555230831 hasConcept C123584848 @default.
- W2555230831 hasConcept C126322002 @default.
- W2555230831 hasConcept C134018914 @default.
- W2555230831 hasConcept C149011108 @default.
- W2555230831 hasConcept C16613235 @default.
- W2555230831 hasConcept C168785527 @default.
- W2555230831 hasConcept C170493617 @default.
- W2555230831 hasConcept C178790620 @default.
- W2555230831 hasConcept C185592680 @default.
- W2555230831 hasConcept C188053792 @default.
- W2555230831 hasConcept C189613389 @default.
- W2555230831 hasConcept C2775864247 @default.
- W2555230831 hasConcept C2778435403 @default.
- W2555230831 hasConcept C2780091579 @default.
- W2555230831 hasConcept C537181965 @default.
- W2555230831 hasConcept C55493867 @default.
- W2555230831 hasConcept C63645605 @default.
- W2555230831 hasConcept C71924100 @default.
- W2555230831 hasConcept C86803240 @default.
- W2555230831 hasConcept C99631742 @default.
- W2555230831 hasConceptScore W2555230831C104317684 @default.