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• W2555239285 abstract "Characterization of mice with cell-specific deletion or overexpression of the mineralocorticoid receptor (MR) shed a new light on its role in health and disease. Pathophysiological MR activation contributes to a plethora of deleterious molecular mechanisms in the development of cardiorenal diseases like chronic kidney disease (CKD) and heart failure (HF). Accordingly, the available steroidal MR antagonists (MRAs) spironolactone (first generation MRA) and eplerenone (second generation MRA) have been shown to be effective in reducing cardiovascular (CV) mortality and morbidity in patients with chronic HF and a reduced left ventricular ejection fraction (HFrEF). However, they remain underutilized, in large part owing to the risk inducing severe adverse events including hyperkalemia and worsening of kidney function, particularly when given on top of inhibitors of the renin angiotensin system (RAS) to patients with concomitant kidney dysfunction. Novel, potent, and selective non-steroidal MRAs (third generation) were identified in drug discovery campaigns and a few entered clinical development recently. One of these is finerenone with different physicochemical, pharmacokinetics, and pharmacological properties in comparison with the steroidal MRAs. Available data from five clinical phase II trials with finerenone in more than 2,000 patients with HF and additional CKD and/or diabetes as well as in patients with diabetic kidney disease demonstrated that neither hyperkalemia nor reductions in kidney function were limiting factors to its use. Moreover, finerenone demonstrated a nominally improved outcome compared to eplerenone in a phase IIb trial with 1,066 patients with HFrEF and concomitant type 2 diabetes mellitus (T2DM) and/or CKD." @default.
• W2555239285 created "2016-11-30" @default.
• W2555239285 creator A5000418035 @default.
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• W2555239285 creator A5061827333 @default.
• W2555239285 date "2016-01-01" @default.
• W2555239285 modified "2023-10-18" @default.
• W2555239285 title "Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside" @default.
• W2555239285 cites W1511208491 @default.
• W2555239285 cites W1574144538 @default.
• W2555239285 cites W1652096387 @default.
• W2555239285 cites W1669115597 @default.
• W2555239285 cites W1830102405 @default.
• W2555239285 cites W1904700712 @default.
• W2555239285 cites W1912334433 @default.
• W2555239285 cites W1929982114 @default.
• W2555239285 cites W1965227811 @default.
• W2555239285 cites W1965301500 @default.
• W2555239285 cites W1965783061 @default.
• W2555239285 cites W1966962224 @default.
• W2555239285 cites W1968355808 @default.
• W2555239285 cites W1968971519 @default.
• W2555239285 cites W1970519405 @default.
• W2555239285 cites W1971136179 @default.
• W2555239285 cites W1971680322 @default.
• W2555239285 cites W1973849316 @default.
• W2555239285 cites W1977186839 @default.
• W2555239285 cites W1979734761 @default.
• W2555239285 cites W1980094514 @default.
• W2555239285 cites W1981681036 @default.
• W2555239285 cites W1985646539 @default.
• W2555239285 cites W1988582819 @default.
• W2555239285 cites W1990240120 @default.
• W2555239285 cites W1994398034 @default.
• W2555239285 cites W1995342392 @default.
• W2555239285 cites W1997062534 @default.
• W2555239285 cites W1997218996 @default.
• W2555239285 cites W1997676536 @default.
• W2555239285 cites W1999112893 @default.
• W2555239285 cites W2000625714 @default.
• W2555239285 cites W2001769042 @default.
• W2555239285 cites W2002009078 @default.
• W2555239285 cites W2005046318 @default.
• W2555239285 cites W2007589695 @default.
• W2555239285 cites W2008704689 @default.
• W2555239285 cites W2012631324 @default.
• W2555239285 cites W2013754344 @default.
• W2555239285 cites W2015497140 @default.
• W2555239285 cites W2019223575 @default.
• W2555239285 cites W2019796933 @default.
• W2555239285 cites W2020920396 @default.
• W2555239285 cites W2023938374 @default.
• W2555239285 cites W2031897773 @default.
• W2555239285 cites W2036043627 @default.
• W2555239285 cites W2037259242 @default.
• W2555239285 cites W2038954842 @default.
• W2555239285 cites W2039006773 @default.
• W2555239285 cites W2039340160 @default.
• W2555239285 cites W2044787154 @default.
• W2555239285 cites W2045027877 @default.
• W2555239285 cites W2045389096 @default.
• W2555239285 cites W2045714553 @default.
• W2555239285 cites W2049772614 @default.
• W2555239285 cites W2050856345 @default.
• W2555239285 cites W2052724934 @default.
• W2555239285 cites W2055730671 @default.
• W2555239285 cites W2059919002 @default.
• W2555239285 cites W2060481021 @default.
• W2555239285 cites W2063921946 @default.
• W2555239285 cites W2067931813 @default.
• W2555239285 cites W2067958388 @default.
• W2555239285 cites W2072078201 @default.
• W2555239285 cites W2072124509 @default.
• W2555239285 cites W2079169053 @default.
• W2555239285 cites W2079266078 @default.
• W2555239285 cites W2080434175 @default.
• W2555239285 cites W2081005181 @default.
• W2555239285 cites W2085832908 @default.
• W2555239285 cites W2085992967 @default.
• W2555239285 cites W2091501358 @default.
• W2555239285 cites W2093131177 @default.
• W2555239285 cites W2095441165 @default.
• W2555239285 cites W2096158094 @default.
• W2555239285 cites W2096875294 @default.
• W2555239285 cites W2104209472 @default.
• W2555239285 cites W2105731611 @default.
• W2555239285 cites W2106052381 @default.
• W2555239285 cites W2106344589 @default.
• W2555239285 cites W2106493153 @default.
• W2555239285 cites W2111945961 @default.
• W2555239285 cites W2115443739 @default.
• W2555239285 cites W2116087989 @default.
• W2555239285 cites W2116687798 @default.
• W2555239285 cites W2117451333 @default.
• W2555239285 cites W2118113989 @default.

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