FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555282437> ?p ?o ?g. }

• W2555282437 abstract "Abstract Purpose: To describe and compare the pre-treatment bone marrow metagenomes of childhood acute lymphoblastic leukemia (ALL) and childhood acute myeloid leukemia (AML). Background: Leukemia is the most common cancer in children, comprised mainly of ALL (~80%) followed by AML (~17%). The role of infections and their timing in the etiology of pre B-cell ALL's (but not AML's) is supported by a considerable body of epidemiologic evidence developed in the past 20 years (Gilham, Peto et al. 2005, Ma, Urayama et al. 2009). There are two main infection related hypotheses. Greaves postulates that delayed infection, akin to the hygiene hypothesis, increases risk of leukemia (Greaves and Alexander 1993, Greaves 1997). The second hypothesis set forth by Kinlen is not mutually exclusive and postulates the role of a transforming yet common virus where introduction of the infectious agent to previously naive communities trigger leukemia (Kinlen 1995). While many viral agents have been investigated (reviewed in (O'Connor and Boneva 2007)) no definitive infectious agent has been identified but, until recently, broad surveys of the microbiome were not possible. Recent developments in next generation sequencing and bioinformatics now allow for unbiased investigation into the totality of organisms that inhabit the human body. Methods: Pre-treatment bone marrow specimens were collected in pre B-cell ALL and AML cases participating in the California Childhood Leukemia Study. AML's with similar age distribution to the ALL's were utilized as controls, to represent the infection history of an immune suppressed child. We interrogated the viral metagenomes of 60 ALL’s and 30 AML’s, pooled and reduced with ribosomal capture, then sequenced with high coverage next generation RNA sequencing on an Illumina HiSeq 2500. The resulting sequences were analyzed using a custom bioinformatics pipeline, DARK, to remove human sequences, to identify viral transcripts, and to categorize all transcripts present in the pre-treatment bone marrow. Bacterial metagenomes of the same subjects were analyzed using 16S rRNA amplicon sequencing and the QIIME pipeline. Results: We analyzed over 500 million 100bp reads and categorized human, non-human and unknown sequences. We found striking differences between the viral metagenomes of childhood ALL and AML, with ALL subjects presenting with a greater viral infection load than AML’s. Furthermore, differences in the presence of transcripts aligning to both exogenous viruses and endogenous retroviruses were observed with some viruses occurring exclusively in ALL’s. We found no difference between the bacterial metagenomes of childhood ALL and AML suggesting no differential contamination occurred during collection and analysis. Discussion: This study provides the first measurement of all identifiable infectious agents in both childhood ALL an AML. Our data suggest that bacteria do not play a role in the etiology of ALL. The greater number and frequency of viral infectious agents were observed in ALL versus AML contribute to an etiologic hypothesis of ALL involving viral infections yet require replication and additional follow up. Moreover the clinical relevance of these infections and their relation to outcome should be investigated. References Gilham, C., J. Peto, J. Simpson, E. Roman, T. O. Eden, M. F. Greaves, F. E. Alexander and U. Investigators (2005). Day care in infancy and risk of childhood acute lymphoblastic leukaemia: findings from UK case-control study. BMJ 330(7503): 1294. Greaves, M. F. (1997). Aetiology of acute leukaemia. Lancet 349(9048): 344-349. Greaves, M. F. and F. E. Alexander (1993). An infectious etiology for common acute lymphoblastic leukemia in childhood? Leukemia 7(3): 349-360. Kinlen, L. J. (1995). Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer 71(1): 1-5. Ma, X., K. Urayama, J. Chang, J. L. Wiemels and P. A. Buffler (2009). Infection and pediatric acute lymphoblastic leukemia. Blood Cells Mol Dis 42(2): 117-120. O'Connor, S. M. and R. S. Boneva (2007). Infectious etiologies of childhood leukemia: plausibility and challenges to proof. Environ Health Perspect 115(1): 146-150. Disclosures No relevant conflicts of interest to declare." @default.
• W2555282437 created "2016-11-30" @default.
• W2555282437 creator A5011390942 @default.
• W2555282437 creator A5019240443 @default.
• W2555282437 creator A5031603638 @default.
• W2555282437 creator A5043076766 @default.
• W2555282437 creator A5052401008 @default.
• W2555282437 creator A5059955772 @default.
• W2555282437 creator A5064203529 @default.
• W2555282437 date "2014-12-06" @default.
• W2555282437 modified "2023-09-28" @default.
• W2555282437 title "Bone Marrow Microbiome: Metagenomic Comparsion of Childhood Acute Lymphoblastic and Acute Myeloid Leukamias" @default.
• W2555282437 doi "https://doi.org/10.1182/blood.v124.21.3771.3771" @default.
• W2555282437 hasPublicationYear "2014" @default.
• W2555282437 type Work @default.
• W2555282437 sameAs 2555282437 @default.
• W2555282437 citedByCount "0" @default.
• W2555282437 crossrefType "journal-article" @default.
• W2555282437 hasAuthorship W2555282437A5011390942 @default.
• W2555282437 hasAuthorship W2555282437A5019240443 @default.
• W2555282437 hasAuthorship W2555282437A5031603638 @default.
• W2555282437 hasAuthorship W2555282437A5043076766 @default.
• W2555282437 hasAuthorship W2555282437A5052401008 @default.
• W2555282437 hasAuthorship W2555282437A5059955772 @default.
• W2555282437 hasAuthorship W2555282437A5064203529 @default.
• W2555282437 hasConcept C121608353 @default.
• W2555282437 hasConcept C126322002 @default.
• W2555282437 hasConcept C143121216 @default.
• W2555282437 hasConcept C203014093 @default.
• W2555282437 hasConcept C2778461978 @default.
• W2555282437 hasConcept C2778729363 @default.
• W2555282437 hasConcept C2779401946 @default.
• W2555282437 hasConcept C2780007613 @default.
• W2555282437 hasConcept C2781107101 @default.
• W2555282437 hasConcept C2909962599 @default.
• W2555282437 hasConcept C60644358 @default.
• W2555282437 hasConcept C71924100 @default.
• W2555282437 hasConcept C86803240 @default.
• W2555282437 hasConceptScore W2555282437C121608353 @default.
• W2555282437 hasConceptScore W2555282437C126322002 @default.
• W2555282437 hasConceptScore W2555282437C143121216 @default.
• W2555282437 hasConceptScore W2555282437C203014093 @default.
• W2555282437 hasConceptScore W2555282437C2778461978 @default.
• W2555282437 hasConceptScore W2555282437C2778729363 @default.
• W2555282437 hasConceptScore W2555282437C2779401946 @default.
• W2555282437 hasConceptScore W2555282437C2780007613 @default.
• W2555282437 hasConceptScore W2555282437C2781107101 @default.
• W2555282437 hasConceptScore W2555282437C2909962599 @default.
• W2555282437 hasConceptScore W2555282437C60644358 @default.
• W2555282437 hasConceptScore W2555282437C71924100 @default.
• W2555282437 hasConceptScore W2555282437C86803240 @default.
• W2555282437 hasLocation W25552824371 @default.
• W2555282437 hasOpenAccess W2555282437 @default.
• W2555282437 hasPrimaryLocation W25552824371 @default.
• W2555282437 hasRelatedWork W1972451741 @default.
• W2555282437 hasRelatedWork W1974924398 @default.
• W2555282437 hasRelatedWork W1977129379 @default.
• W2555282437 hasRelatedWork W1992423687 @default.
• W2555282437 hasRelatedWork W2003821659 @default.
• W2555282437 hasRelatedWork W2019249796 @default.
• W2555282437 hasRelatedWork W2095405591 @default.
• W2555282437 hasRelatedWork W2105233965 @default.
• W2555282437 hasRelatedWork W2115917264 @default.
• W2555282437 hasRelatedWork W2116758852 @default.
• W2555282437 hasRelatedWork W2117001035 @default.
• W2555282437 hasRelatedWork W2142540608 @default.
• W2555282437 hasRelatedWork W2157783208 @default.
• W2555282437 hasRelatedWork W2158290056 @default.
• W2555282437 hasRelatedWork W2181015690 @default.
• W2555282437 hasRelatedWork W2573935176 @default.
• W2555282437 hasRelatedWork W2912654636 @default.
• W2555282437 hasRelatedWork W3196453395 @default.
• W2555282437 hasRelatedWork W3197484322 @default.
• W2555282437 hasRelatedWork W2398171819 @default.
• W2555282437 isParatext "false" @default.
• W2555282437 isRetracted "false" @default.
• W2555282437 magId "2555282437" @default.
• W2555282437 workType "article" @default.