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• W2555318998 abstract "// Weiyun Wu 1, * , Yanting He 1, * , Xiao Feng 1 , Shicai Ye 1 , Hao Wang 1 , Wenkai Tan 1 , Caiyuan Yu 1 , Juxiang Hu 1 , Rong Zheng 1 , Yu Zhou 1 1 Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China * These authors contributed equally to this work Correspondence to: Yu Zhou, email: ahdg2005@126.com Keywords: miRNA-206, ulcerative colitis, adenosine A3 receptor, NF-κB Received: June 09, 2016      Accepted: November 12, 2016      Published: November 23, 2016 ABSTRACT Increasing evidence suggests that miRNAs are widely dysregulated in ulcerative colitis (UC), potentially affecting UC pathogenesis, diagnosis, and therapy. microRNA (miR) -206 has been reported to be upregulated in UC; however, its function and role in UC remain unknown. Here, we elucidate the function of miR-206 in the pathogenesis of UC. In patients with active-UC, miR-206 and adenosine A3 receptor (A3AR) levels were significantly upregulated and downregulated, respectively, and were inversely correlated. A3AR was expressed in the colon mucosa (particularly in colon epithelial-cell membranes). In HT-29 cells, miR-206 downregulated A3AR mRNA/protein expression by directly targeting the A3AR 3′-UTR; miR-206 overexpression and knockdown respectively increased and decreased TNF-α-induced nuclear NF-κB/p65, p-IκB-α, IKKα, p-IKKα and IL-8/IL-1β secretion. However, A3AR-siRNA reversed the miR-206 inhibitory effect. Furthermore, miR-206 increased dextran sodium sulphate-induced colitis severity (i.e., increased bodyweight loss, DAI score, colon shrinkage, and MPO activity), which was partially ameliorated by miR-206-antagomir treatment. miR-206-agomir treatment potently suppressed A3AR expression and increased NF-κB signalling and downstream cytokine (TNF-α/IL-8/IL-1β) expression in the mouse colon, in contrast to miR-206-antagomir administration. Taken together, our results demonstrated that miR-206 has a proinflammatory role in UC by downregulating A3AR expression and activating NF-κB signalling." @default.
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• W2555318998 date "2016-11-23" @default.
• W2555318998 modified "2023-10-16" @default.
• W2555318998 title "MicroRNA-206 is involved in the pathogenesis of ulcerative colitis via regulation of adenosine A3 receptor" @default.
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• W2555318998 doi "https://doi.org/10.18632/oncotarget.13525" @default.
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