FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555363519> ?p ?o ?g. }

• W2555363519 endingPage "45" @default.
• W2555363519 startingPage "40" @default.
• W2555363519 abstract "Lung cancer early detection by low-dose computed tomography (LDCT) can reduce the mortality. However, LDCT increases the number of indeterminate pulmonary nodules (PNs), whereas 95% of the PNs are ultimately false positives. Modalities for specifically distinguishing between malignant and benign PNs are urgently needed. We previously identified a panel of peripheral blood mononucleated cell (PBMC)-miRNA (miRs-19b-3p and -29b-3p) biomarkers for lung cancer. This study aimed to evaluate efficacy of integrating biomarkers and clinical and radiological characteristics of smokers for differentiating malignant from benign PNs. We analyzed expression of 2 miRNAs (miRs-19b-3p and -29b-3p) in PBMCs of a training set of 137 individuals with PNs. We used multivariate logistic regression analysis to develop a prediction model based on the biomarkers, radiographic features of PNs, and clinical characteristics of smokers for identifying malignant PNs. The performance of the prediction model was validated in a testing set of 111 subjects with PNs. A prediction model comprising the two biomarkers, spiculation of PNs and smoking pack-year, was developed that had 0.91 area under the curve of the receiver operating characteristic for distinguishing malignant from benign PNs. The prediction model yielded higher sensitivity (80.3% vs 72.6%) and specificity (89.4% vs 81.9%) compared with the biomarkers used alone (all P < .05). The performance of the prediction model for malignant PNs was confirmed in the validation set. We have for the first time demonstrated that the integration of biomarkers and clinical and radiological characteristics could efficiently identify lung cancer among indeterminate PNs." @default.
• W2555363519 created "2016-11-30" @default.
• W2555363519 creator A5019944599 @default.
• W2555363519 creator A5044315460 @default.
• W2555363519 creator A5048662409 @default.
• W2555363519 creator A5076571826 @default.
• W2555363519 creator A5091816719 @default.
• W2555363519 date "2017-02-01" @default.
• W2555363519 modified "2023-09-26" @default.
• W2555363519 title "A Prediction Model Based on Biomarkers and Clinical Characteristics for Detection of Lung Cancer in Pulmonary Nodules" @default.
• W2555363519 cites W1213336605 @default.
• W2555363519 cites W130099911 @default.
• W2555363519 cites W1987872348 @default.
• W2555363519 cites W1999529880 @default.
• W2555363519 cites W2000982792 @default.
• W2555363519 cites W2012530339 @default.
• W2555363519 cites W2019416184 @default.
• W2555363519 cites W2020089990 @default.
• W2555363519 cites W2020928848 @default.
• W2555363519 cites W2031166360 @default.
• W2555363519 cites W2102150307 @default.
• W2555363519 cites W2107692993 @default.
• W2555363519 cites W2114175038 @default.
• W2555363519 cites W2114374668 @default.
• W2555363519 cites W2116004692 @default.
• W2555363519 cites W2116616871 @default.
• W2555363519 cites W2117991242 @default.
• W2555363519 cites W2134453734 @default.
• W2555363519 cites W2139277921 @default.
• W2555363519 cites W2149385948 @default.
• W2555363519 cites W2150124099 @default.
• W2555363519 cites W2159627693 @default.
• W2555363519 cites W2464326114 @default.
• W2555363519 cites W4238000814 @default.
• W2555363519 doi "https://doi.org/10.1016/j.tranon.2016.11.001" @default.
• W2555363519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5126145" @default.
• W2555363519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27889655" @default.
• W2555363519 hasPublicationYear "2017" @default.
• W2555363519 type Work @default.
• W2555363519 sameAs 2555363519 @default.
• W2555363519 citedByCount "15" @default.
• W2555363519 countsByYear W25553635192017 @default.
• W2555363519 countsByYear W25553635192018 @default.
• W2555363519 countsByYear W25553635192019 @default.
• W2555363519 countsByYear W25553635192020 @default.
• W2555363519 countsByYear W25553635192021 @default.
• W2555363519 countsByYear W25553635192022 @default.
• W2555363519 countsByYear W25553635192023 @default.
• W2555363519 crossrefType "journal-article" @default.
• W2555363519 hasAuthorship W2555363519A5019944599 @default.
• W2555363519 hasAuthorship W2555363519A5044315460 @default.
• W2555363519 hasAuthorship W2555363519A5048662409 @default.
• W2555363519 hasAuthorship W2555363519A5076571826 @default.
• W2555363519 hasAuthorship W2555363519A5091816719 @default.
• W2555363519 hasBestOaLocation W25553635191 @default.
• W2555363519 hasConcept C119857082 @default.
• W2555363519 hasConcept C121608353 @default.
• W2555363519 hasConcept C126322002 @default.
• W2555363519 hasConcept C126838900 @default.
• W2555363519 hasConcept C142724271 @default.
• W2555363519 hasConcept C143998085 @default.
• W2555363519 hasConcept C151956035 @default.
• W2555363519 hasConcept C2776256026 @default.
• W2555363519 hasConcept C2777714996 @default.
• W2555363519 hasConcept C41008148 @default.
• W2555363519 hasConcept C58471807 @default.
• W2555363519 hasConcept C64869954 @default.
• W2555363519 hasConcept C71924100 @default.
• W2555363519 hasConceptScore W2555363519C119857082 @default.
• W2555363519 hasConceptScore W2555363519C121608353 @default.
• W2555363519 hasConceptScore W2555363519C126322002 @default.
• W2555363519 hasConceptScore W2555363519C126838900 @default.
• W2555363519 hasConceptScore W2555363519C142724271 @default.
• W2555363519 hasConceptScore W2555363519C143998085 @default.
• W2555363519 hasConceptScore W2555363519C151956035 @default.
• W2555363519 hasConceptScore W2555363519C2776256026 @default.
• W2555363519 hasConceptScore W2555363519C2777714996 @default.
• W2555363519 hasConceptScore W2555363519C41008148 @default.
• W2555363519 hasConceptScore W2555363519C58471807 @default.
• W2555363519 hasConceptScore W2555363519C64869954 @default.
• W2555363519 hasConceptScore W2555363519C71924100 @default.
• W2555363519 hasIssue "1" @default.
• W2555363519 hasLocation W25553635191 @default.
• W2555363519 hasLocation W25553635192 @default.
• W2555363519 hasLocation W25553635193 @default.
• W2555363519 hasLocation W25553635194 @default.
• W2555363519 hasOpenAccess W2555363519 @default.
• W2555363519 hasPrimaryLocation W25553635191 @default.
• W2555363519 hasRelatedWork W1967103478 @default.
• W2555363519 hasRelatedWork W2032912323 @default.
• W2555363519 hasRelatedWork W2049214470 @default.
• W2555363519 hasRelatedWork W2171288501 @default.
• W2555363519 hasRelatedWork W2348566799 @default.
• W2555363519 hasRelatedWork W2372561159 @default.
• W2555363519 hasRelatedWork W2375344515 @default.
• W2555363519 hasRelatedWork W2389709268 @default.
• W2555363519 hasRelatedWork W2390152934 @default.
• W2555363519 hasRelatedWork W2770058211 @default.

• next