FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555364244> ?p ?o ?g. }

• W2555364244 endingPage "2266" @default.
• W2555364244 startingPage "2250" @default.
• W2555364244 abstract "Combination therapy is an emerging strategy that is under intensive preclinical investigation for the treatment of various diseases. CD98 is highly overexpressed on the surfaces of epithelial cells and macrophages in the colon tissue with ulcerative colitis (UC), which is usually associated with mucosal damage and inflammation. We previously proved that CD98 siRNA (siCD98)-induced down-regulation of CD98 in colitis tissue decreased the severity of UC to a certain extent. In an effort to further improve the therapeutic efficacy, we aim to simultaneously deliver siCD98 in combination with a potent anti-inflammatory agent, curcumin (CUR), using hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant spherical HA-siCD98/CUR-NPs are featured by a desirable particle size (∼246 nm) and slightly negative zeta potential (∼-14 mV). The NPs functionalized with HA are able to guide the co-delivery of drugs to the targeted cells related to UC therapy (colonic epithelial cells and macrophages). Compared to either siCD98- or CUR-based monotherapy, co-delivery of siCD98 and CUR by HA-functionalized NPs can exert combinational effects against UC by protecting the mucosal layer and alleviating inflammation both in vitro and in vivo. This study shows the promising capability of the co-delivered siCD98 and CUR for boosting the conventional monotherapy via this novel nanotherapeutic agent, which offers a structurally simple platform for orally administered delivery of drugs to target cells in UC therapy." @default.
• W2555364244 created "2016-11-30" @default.
• W2555364244 creator A5015974964 @default.
• W2555364244 creator A5016005359 @default.
• W2555364244 creator A5029728983 @default.
• W2555364244 creator A5047305591 @default.
• W2555364244 creator A5054398705 @default.
• W2555364244 creator A5057013023 @default.
• W2555364244 creator A5058080897 @default.
• W2555364244 creator A5076763514 @default.
• W2555364244 date "2016-01-01" @default.
• W2555364244 modified "2023-09-30" @default.
• W2555364244 title "Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation" @default.
• W2555364244 cites W1530059316 @default.
• W2555364244 cites W1801904186 @default.
• W2555364244 cites W1963526834 @default.
• W2555364244 cites W1964102710 @default.
• W2555364244 cites W1966063759 @default.
• W2555364244 cites W1979996162 @default.
• W2555364244 cites W1982500127 @default.
• W2555364244 cites W1987351596 @default.
• W2555364244 cites W1990444829 @default.
• W2555364244 cites W1992529637 @default.
• W2555364244 cites W1994720283 @default.
• W2555364244 cites W2003176104 @default.
• W2555364244 cites W2004750142 @default.
• W2555364244 cites W2006595429 @default.
• W2555364244 cites W2007860338 @default.
• W2555364244 cites W2011905672 @default.
• W2555364244 cites W2016054780 @default.
• W2555364244 cites W2016195406 @default.
• W2555364244 cites W2017560192 @default.
• W2555364244 cites W2020220189 @default.
• W2555364244 cites W2026756786 @default.
• W2555364244 cites W2029983315 @default.
• W2555364244 cites W2031104374 @default.
• W2555364244 cites W2032175829 @default.
• W2555364244 cites W2033661027 @default.
• W2555364244 cites W2047101821 @default.
• W2555364244 cites W2048584498 @default.
• W2555364244 cites W2060140728 @default.
• W2555364244 cites W2060400002 @default.
• W2555364244 cites W2063959469 @default.
• W2555364244 cites W2071814151 @default.
• W2555364244 cites W2076811169 @default.
• W2555364244 cites W2077166822 @default.
• W2555364244 cites W2082419507 @default.
• W2555364244 cites W2082748819 @default.
• W2555364244 cites W2082884465 @default.
• W2555364244 cites W2099166156 @default.
• W2555364244 cites W2100439220 @default.
• W2555364244 cites W2103029026 @default.
• W2555364244 cites W2118042314 @default.
• W2555364244 cites W2121566098 @default.
• W2555364244 cites W2129855398 @default.
• W2555364244 cites W2131490500 @default.
• W2555364244 cites W2141696954 @default.
• W2555364244 cites W2144331651 @default.
• W2555364244 cites W2150375936 @default.
• W2555364244 cites W2155464400 @default.
• W2555364244 cites W2157983266 @default.
• W2555364244 cites W2158787062 @default.
• W2555364244 cites W2168184580 @default.
• W2555364244 cites W2233432152 @default.
• W2555364244 cites W2257473733 @default.
• W2555364244 cites W4244626580 @default.
• W2555364244 cites W43532378 @default.
• W2555364244 doi "https://doi.org/10.7150/thno.15710" @default.
• W2555364244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5135446" @default.
• W2555364244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27924161" @default.
• W2555364244 hasPublicationYear "2016" @default.
• W2555364244 type Work @default.
• W2555364244 sameAs 2555364244 @default.
• W2555364244 citedByCount "153" @default.
• W2555364244 countsByYear W25553642442017 @default.
• W2555364244 countsByYear W25553642442018 @default.
• W2555364244 countsByYear W25553642442019 @default.
• W2555364244 countsByYear W25553642442020 @default.
• W2555364244 countsByYear W25553642442021 @default.
• W2555364244 countsByYear W25553642442022 @default.
• W2555364244 countsByYear W25553642442023 @default.
• W2555364244 crossrefType "journal-article" @default.
• W2555364244 hasAuthorship W2555364244A5015974964 @default.
• W2555364244 hasAuthorship W2555364244A5016005359 @default.
• W2555364244 hasAuthorship W2555364244A5029728983 @default.
• W2555364244 hasAuthorship W2555364244A5047305591 @default.
• W2555364244 hasAuthorship W2555364244A5054398705 @default.
• W2555364244 hasAuthorship W2555364244A5057013023 @default.
• W2555364244 hasAuthorship W2555364244A5058080897 @default.
• W2555364244 hasAuthorship W2555364244A5076763514 @default.
• W2555364244 hasBestOaLocation W25553642441 @default.
• W2555364244 hasConcept C105702510 @default.
• W2555364244 hasConcept C142724271 @default.
• W2555364244 hasConcept C150903083 @default.
• W2555364244 hasConcept C185592680 @default.
• W2555364244 hasConcept C202751555 @default.
• W2555364244 hasConcept C203014093 @default.
• W2555364244 hasConcept C207001950 @default.

• next