FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555397029> ?p ?o ?g. }

• W2555397029 endingPage "535" @default.
• W2555397029 startingPage "528" @default.
• W2555397029 abstract "Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1Y431 * mutant zebrafish (Danio rerio) via rescue of mitochondrial respiratory chain function. In contrast, genetic inactivation of the voltage dependent anion channel 1 (VDAC1), located in the outer mitochondrial membrane, did not rescue dopaminergic neurons in PINK1 deficient D. rerio. Subsequent gene expression studies revealed specific upregulation of the mcu regulator micu1 in pink1Y431 * mutant zebrafish larvae and inactivation of micu1 also results in rescue of dopaminergic neurons. The functional consequences of PINK1 deficiency and modified MCU activity were confirmed using a dynamic in silico model of Ca2+ triggered mitochondrial activity. Our data suggest modulation of MCU-mediated mitochondrial calcium homeostasis as a possible neuroprotective strategy in PINK1 mutant PD." @default.
• W2555397029 created "2016-11-30" @default.
• W2555397029 creator A5013342329 @default.
• W2555397029 creator A5026621001 @default.
• W2555397029 creator A5036488661 @default.
• W2555397029 creator A5044417399 @default.
• W2555397029 creator A5055431881 @default.
• W2555397029 creator A5058513528 @default.
• W2555397029 creator A5064533046 @default.
• W2555397029 creator A5078674247 @default.
• W2555397029 creator A5080282776 @default.
• W2555397029 creator A5084751027 @default.
• W2555397029 date "2016-12-28" @default.
• W2555397029 modified "2023-10-17" @default.
• W2555397029 title "Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in<i>pink1</i>^{<i>−</i>/<i>−</i>}zebrafish" @default.
• W2555397029 cites W1436188216 @default.
• W2555397029 cites W1584798972 @default.
• W2555397029 cites W1962379540 @default.
• W2555397029 cites W1978327835 @default.
• W2555397029 cites W1981239255 @default.
• W2555397029 cites W1986213783 @default.
• W2555397029 cites W1988741146 @default.
• W2555397029 cites W2005641666 @default.
• W2555397029 cites W2019790479 @default.
• W2555397029 cites W2026946582 @default.
• W2555397029 cites W2031207947 @default.
• W2555397029 cites W2034087770 @default.
• W2555397029 cites W2035213438 @default.
• W2555397029 cites W2053188090 @default.
• W2555397029 cites W2057636635 @default.
• W2555397029 cites W2058521767 @default.
• W2555397029 cites W2059463965 @default.
• W2555397029 cites W2067841051 @default.
• W2555397029 cites W2069013650 @default.
• W2555397029 cites W2085554856 @default.
• W2555397029 cites W2097021021 @default.
• W2555397029 cites W2106466768 @default.
• W2555397029 cites W2108575498 @default.
• W2555397029 cites W2109326232 @default.
• W2555397029 cites W2112384117 @default.
• W2555397029 cites W2115524420 @default.
• W2555397029 cites W2126475226 @default.
• W2555397029 cites W2135014000 @default.
• W2555397029 cites W2136963255 @default.
• W2555397029 cites W2138643436 @default.
• W2555397029 cites W2144096576 @default.
• W2555397029 cites W2165128853 @default.
• W2555397029 cites W2321530006 @default.
• W2555397029 cites W4211123396 @default.
• W2555397029 doi "https://doi.org/10.1111/ejn.13473" @default.
• W2555397029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5324670" @default.
• W2555397029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27859782" @default.
• W2555397029 hasPublicationYear "2016" @default.
• W2555397029 type Work @default.
• W2555397029 sameAs 2555397029 @default.
• W2555397029 citedByCount "69" @default.
• W2555397029 countsByYear W25553970292017 @default.
• W2555397029 countsByYear W25553970292018 @default.
• W2555397029 countsByYear W25553970292019 @default.
• W2555397029 countsByYear W25553970292020 @default.
• W2555397029 countsByYear W25553970292021 @default.
• W2555397029 countsByYear W25553970292022 @default.
• W2555397029 countsByYear W25553970292023 @default.
• W2555397029 crossrefType "journal-article" @default.
• W2555397029 hasAuthorship W2555397029A5013342329 @default.
• W2555397029 hasAuthorship W2555397029A5026621001 @default.
• W2555397029 hasAuthorship W2555397029A5036488661 @default.
• W2555397029 hasAuthorship W2555397029A5044417399 @default.
• W2555397029 hasAuthorship W2555397029A5055431881 @default.
• W2555397029 hasAuthorship W2555397029A5058513528 @default.
• W2555397029 hasAuthorship W2555397029A5064533046 @default.
• W2555397029 hasAuthorship W2555397029A5078674247 @default.
• W2555397029 hasAuthorship W2555397029A5080282776 @default.
• W2555397029 hasAuthorship W2555397029A5084751027 @default.
• W2555397029 hasBestOaLocation W25553970291 @default.
• W2555397029 hasConcept C104317684 @default.
• W2555397029 hasConcept C146587185 @default.
• W2555397029 hasConcept C169760540 @default.
• W2555397029 hasConcept C181199279 @default.
• W2555397029 hasConcept C190283241 @default.
• W2555397029 hasConcept C203522944 @default.
• W2555397029 hasConcept C25498285 @default.
• W2555397029 hasConcept C2776804853 @default.
• W2555397029 hasConcept C2776878037 @default.
• W2555397029 hasConcept C2779058106 @default.
• W2555397029 hasConcept C2779324830 @default.
• W2555397029 hasConcept C28859421 @default.
• W2555397029 hasConcept C31573885 @default.
• W2555397029 hasConcept C35341161 @default.
• W2555397029 hasConcept C547475151 @default.
• W2555397029 hasConcept C55493867 @default.
• W2555397029 hasConcept C86803240 @default.
• W2555397029 hasConcept C95444343 @default.
• W2555397029 hasConcept C98539663 @default.
• W2555397029 hasConceptScore W2555397029C104317684 @default.
• W2555397029 hasConceptScore W2555397029C146587185 @default.
• W2555397029 hasConceptScore W2555397029C169760540 @default.
• W2555397029 hasConceptScore W2555397029C181199279 @default.

• next