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• W2555446678 abstract "Objectives: Phosphodiesterase-5 inhibitors (PDE-5) have been reported to be beneficial in improving exercise capacity and quality of life. However, the response of PDE-5 inhibitors in the setting of low atmospheric oxygen tension among natives of medium altitude has not been reported. Present study reports the effect of tadalafil on exercise capacity and quality of life in patients of chronic pul monary diseases with PH residing at an altitude ranging between 1000 meters to 2500 meters above mean sea level. Material and methods: Seventy six patients of chronic pulmonary diseases with PH diagnosed by echocardiography were randomized to receive tadalafil 40 mg once a day or to the control group and were followed up for three months. The exercise tolerance was assessed by measuring 6-minute walk distance, Borg dyspnea and fatigue score. The quality of life was measured by St George’s Respiratory Questionnaires based scores. The baseline medications were continued during the follow up period in both the groups. Results: Tadalafil significantly improved the 6-minute walk distance (336.7 ± 63.0 meters vs. 290.7 ± 54.4 meters, p < 0.001), Borg dyspnea score (2.9 ± 1.1 vs. 4.0 ± 1.2, p < 0.005), and the Borg fatigue score (2.8 ± 1.13 versus 3.8 ± 1.0, p < 0.005). The quality of life also improved significantly in the tadalafil group (total St George’s Respiratory Questionnaires score 44.3 ± 9.0 vs. 55.8 ± 12.1, p < 0.0005). Tadalafil also improved resting and peak exercise arterial oxygen saturation. Conclusion: In the present study, tadalafil 40mg once daily showed significant improvement in the exercise capacity and quality of life of patients with chronic pulmonary diseases with PH. Trial registration: Central Trial Registry of India, CTRI/2015/01/005413." @default.
• W2555446678 created "2016-11-30" @default.
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• W2555446678 date "2016-01-01" @default.
• W2555446678 modified "2023-09-26" @default.
• W2555446678 title "Effects of Tadalafil on the Exercise Capacity and Quality of Life among Patients of Chronic Pulmonary Diseases with Pulmonary Hypertension: A Pilot Study" @default.
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