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- W2555536701 abstract "Summary The aim of the present study was to investigate the effect of oral administration of ethanolic extract of Stevia rebaudiana Bertoni (Asteraceae) leaves against ethylene glycol+induced nephrolithiasis in albino rats. Lithiasis was induced in rats by administrating 0.75 % v/v ethylene glycol in drinking water for 28 days and was manifested by hyperoxaluria as well as increased renal excretion of calcium, phosphate and low urinary magnesium content. Supplementation with ethanolic extract (100 mg/kg b.w., p.o.) of S. rebaudiana leaves significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was significantly lowered by curative and preventive treatment using ethanolic extract (100 mg/kg b.w., p.o.) of S. rebaudiana leaves. From this study, we conclude that both the prophylactic and therapeutic treatment with ethanolic extract of leaves of S. rebaudiana had an inhibitory effect on crystal growth, with improvement of kidney function as well as cytoprotective effect." @default.
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- W2555536701 date "2010-01-01" @default.
- W2555536701 modified "2023-09-22" @default.
- W2555536701 title "Antilithiatic Effect of Ethanolic Extract of Stevia Rebaudiana Bert" @default.
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