Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555587745> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2555587745 endingPage "741" @default.
- W2555587745 startingPage "735" @default.
- W2555587745 abstract "COX-2 expression induces carcinogenesis and is thought to be an adverse prognostic factor in gastric carcinomas while the prognostic value of DNA mismatch repair (MMR) is still controversial. Concerning adenocarcinomas of the esophagogastric junction, no comprehensive data regarding either factors are available as of yet.We assessed expression of COX-2, MLH1 and MSH2 in adenocarcinoma of the esophagogastric junction in relation to patients' survival and various clinicopathologic features.Immunohistochemical studies (using antibodies against COX-2, MLH1 and MSH2) were performed in a study population of 228 tumours. Follow-up data was available for all patients with a mean follow-up time of 42.8 months.78 (34.2%) tumours were COX-2 negative, 148 (64.9%) showed COX-2 positivity. Assessment of COX-2 expression and clinicopathologic features revealed an inverse correlation with depth of tumour invasion and number of metastatic lymph nodes (p=0,021 and p=0,004, respectively). No correlation with other features could be demonstrated. 62 cases (27.2%) showed loss of DNA repair enzymes MLH1 and/or MSH2. MMR differed significantly between COX-2 positive and negative cases (p=0,028). Kaplan-Meier survival analyses revealed no impact on patients' survival for COX-2 expression or MMR status (p=0.837 and p=0.972, respectively).Expression of COX-2 in adenocarcinomas of the esophagogastric junction seems to have no prognostic effect or impact on patients' survival but is associated with favourable clinicopathologic factors. MMR deficiency was more frequent in COX-2 negative tumours, but MMR status had no impact on survival and patients' outcome whatsoever." @default.
- W2555587745 created "2016-11-30" @default.
- W2555587745 creator A5037378165 @default.
- W2555587745 creator A5038722766 @default.
- W2555587745 creator A5045973184 @default.
- W2555587745 creator A5054027133 @default.
- W2555587745 creator A5064547494 @default.
- W2555587745 creator A5079892703 @default.
- W2555587745 date "2017-07-01" @default.
- W2555587745 modified "2023-09-23" @default.
- W2555587745 title "Expression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic features." @default.
- W2555587745 doi "https://doi.org/10.14670/hh-11-843" @default.
- W2555587745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27854106" @default.
- W2555587745 hasPublicationYear "2017" @default.
- W2555587745 type Work @default.
- W2555587745 sameAs 2555587745 @default.
- W2555587745 citedByCount "0" @default.
- W2555587745 crossrefType "journal-article" @default.
- W2555587745 hasAuthorship W2555587745A5037378165 @default.
- W2555587745 hasAuthorship W2555587745A5038722766 @default.
- W2555587745 hasAuthorship W2555587745A5045973184 @default.
- W2555587745 hasAuthorship W2555587745A5054027133 @default.
- W2555587745 hasAuthorship W2555587745A5064547494 @default.
- W2555587745 hasAuthorship W2555587745A5079892703 @default.
- W2555587745 hasConcept C10515644 @default.
- W2555587745 hasConcept C111425858 @default.
- W2555587745 hasConcept C121608353 @default.
- W2555587745 hasConcept C126322002 @default.
- W2555587745 hasConcept C142724271 @default.
- W2555587745 hasConcept C143998085 @default.
- W2555587745 hasConcept C204232928 @default.
- W2555587745 hasConcept C2776497702 @default.
- W2555587745 hasConcept C2779115348 @default.
- W2555587745 hasConcept C2781182431 @default.
- W2555587745 hasConcept C2908647359 @default.
- W2555587745 hasConcept C50382708 @default.
- W2555587745 hasConcept C526805850 @default.
- W2555587745 hasConcept C60748783 @default.
- W2555587745 hasConcept C71924100 @default.
- W2555587745 hasConcept C90924648 @default.
- W2555587745 hasConcept C99454951 @default.
- W2555587745 hasConceptScore W2555587745C10515644 @default.
- W2555587745 hasConceptScore W2555587745C111425858 @default.
- W2555587745 hasConceptScore W2555587745C121608353 @default.
- W2555587745 hasConceptScore W2555587745C126322002 @default.
- W2555587745 hasConceptScore W2555587745C142724271 @default.
- W2555587745 hasConceptScore W2555587745C143998085 @default.
- W2555587745 hasConceptScore W2555587745C204232928 @default.
- W2555587745 hasConceptScore W2555587745C2776497702 @default.
- W2555587745 hasConceptScore W2555587745C2779115348 @default.
- W2555587745 hasConceptScore W2555587745C2781182431 @default.
- W2555587745 hasConceptScore W2555587745C2908647359 @default.
- W2555587745 hasConceptScore W2555587745C50382708 @default.
- W2555587745 hasConceptScore W2555587745C526805850 @default.
- W2555587745 hasConceptScore W2555587745C60748783 @default.
- W2555587745 hasConceptScore W2555587745C71924100 @default.
- W2555587745 hasConceptScore W2555587745C90924648 @default.
- W2555587745 hasConceptScore W2555587745C99454951 @default.
- W2555587745 hasIssue "7" @default.
- W2555587745 hasLocation W25555877451 @default.
- W2555587745 hasOpenAccess W2555587745 @default.
- W2555587745 hasPrimaryLocation W25555877451 @default.
- W2555587745 hasRelatedWork W1990603731 @default.
- W2555587745 hasRelatedWork W2051175872 @default.
- W2555587745 hasRelatedWork W2152837921 @default.
- W2555587745 hasRelatedWork W2169067777 @default.
- W2555587745 hasRelatedWork W2355800705 @default.
- W2555587745 hasRelatedWork W2883828665 @default.
- W2555587745 hasRelatedWork W3007683801 @default.
- W2555587745 hasRelatedWork W3040417528 @default.
- W2555587745 hasRelatedWork W4221056467 @default.
- W2555587745 hasRelatedWork W76420562 @default.
- W2555587745 hasVolume "32" @default.
- W2555587745 isParatext "false" @default.
- W2555587745 isRetracted "false" @default.
- W2555587745 magId "2555587745" @default.
- W2555587745 workType "article" @default.