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- W2555665215 abstract "Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons. In contrast to the current ascending theory where α-synuclein would propagate from neuron to neuron, we now propose the threshold theory for PD based on evidence of parallel degeneration of both central nervous system (CNS) and peripheral nervous system (PNS) in PD. The functional threshold is lower for the emergence of early symptoms before the classical motor symptoms of PD. This is due to the larger functional reserve of the midbrain dopamine and integrated basal ganglia motor systems to control movement. This threshold theory better accounts for the current neurobiology of PD symptom progression compared to the hypothesis that the disease ascends from the PNS to the CNS as proposed by Braak's hypothesis." @default.
- W2555665215 created "2016-11-30" @default.
- W2555665215 creator A5028593542 @default.
- W2555665215 creator A5058850275 @default.
- W2555665215 date "2017-01-01" @default.
- W2555665215 modified "2023-09-30" @default.
- W2555665215 title "The Threshold Theory for Parkinson's Disease" @default.
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