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- W2555752304 abstract "Introduction: Acute hypoxia during exacerbations of lung disease leads to pulmonary hypertension, contributing to morbidity and mortality. Although pulmonary vasodilator therapy is not beneficial in pulmonary hypertension due to chronic hypoxia in lung disease, effects in acute hypoxia are less well defined. Riociguat is a novel class of pulmonary vasodilator which could potentially ameliorate the acute rise in pulmonary vascular resistance (PVR) and pressure (PAP) mediated by hypoxia. Methods: We established changes in PVR and PAP during acute hypoxia in patients with respiratory disease, before and after chronic dosing of Riociguat. Acute hypoxia was achieved by performing a flight challenge test where 15% oxygen is administered during right heart catheterisation. Results: Seven patients (5 with chronic obstructive pulmonary disease, 2 with interstitial lung disease) were studied. The mean age was 67 years and all had normal saturations. At baseline, the mean increases in PAP and PVR on breathing 15% oxygen were 5.86mmHg and 0.75 Wood units. After Riociguat treatment, the mean increases in PAP and PVR were 2.29mmHg and 0.1 Wood units, both of which were significantly smaller increases compared to baseline (both p values 0.003). Resting oxygen saturations before and after Riociguat were unchanged (p value 0.094). Conclusion: Our study is the first to establish the effects of Riociguat on acute hypoxic pulmonary vasoconstriction. Our preliminary results show that Riociguat reduces the rise in PVR and PAP during acute hypoxia. Further studies would be warranted to establish if Riociguat would be effective in preventing right heart failure in acute exacerbations of lung disease." @default.
- W2555752304 created "2016-11-30" @default.
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- W2555752304 date "2016-09-01" @default.
- W2555752304 modified "2023-09-27" @default.
- W2555752304 title "The effect of chronic dosing of riociguat on acute hypoxic pulmonary vasoconstriction in respiratory disease" @default.
- W2555752304 doi "https://doi.org/10.1183/13993003.congress-2016.pa2436" @default.
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