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- W2555816384 abstract "John W. Saunders, Jr. made seminal discoveries unveiling how chick embryos develop their limbs. He discovered the apical ectodermal ridge (AER), the zone of polarizing activity (ZPA), and the domains of interdigital cell death within the developing limb and determined their function through experimental analysis. These discoveries provided the basis for subsequent molecular understanding of how vertebrate limbs are induced, patterned, and differentiated. These mechanisms are strongly conserved among the vast diversity of tetrapod limbs suggesting that relatively minor changes and tweaks to the molecular cascades are responsible for the diversity observed in nature. Analysis of the pathway systems first identified by Saunders in the context of animals displaying limb reduction show how alterations in these pathways have resulted in multiple mechanisms of limb and digit loss. Other classes of modification to these same patterning systems are seen at the root of other, novel limb morphological alterations and elaborations." @default.
- W2555816384 created "2016-11-30" @default.
- W2555816384 creator A5014300544 @default.
- W2555816384 creator A5018051847 @default.
- W2555816384 date "2017-09-01" @default.
- W2555816384 modified "2023-09-24" @default.
- W2555816384 title "Saunders's framework for understanding limb development as a platform for investigating limb evolution" @default.
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- W2555816384 doi "https://doi.org/10.1016/j.ydbio.2016.11.005" @default.
- W2555816384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5426996" @default.
- W2555816384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27840200" @default.
- W2555816384 hasPublicationYear "2017" @default.
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