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- W2555823385 abstract "The complement C4 is a thioester-containing protein, and a histidine (H) residue catalyzes the cleavage of the thioester to allow covalent binding to carbohydrates on target cells. Some mammalian and teleost species possess an additional isotype where the catalytic H is replaced by an aspartic acid (D), which binds preferentially to proteins. We found the two C4 isotypes in many other jawed vertebrates, including sharks and birds/reptiles. Phylogenetic analysis suggested that C4 gene duplication occurred in the early days of the jawed vertebrate evolution. The D-type C4 of bony fish except for mammals formed a cluster, termed D-lineage. The D-lineage genes were located in a syntenic region outside MHC, and evolved conservatively. Mammals lost the D-lineage before speciation, but D-type C4 was regenerated by recent gene duplication in some mammalian species or groups. Dual C4 molecules with different substrate specificities would have contributed to development of the antibody-dependent classical pathway." @default.
- W2555823385 created "2016-11-30" @default.
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- W2555823385 date "2017-03-01" @default.
- W2555823385 modified "2023-10-03" @default.
- W2555823385 title "Evolutionary analysis of two complement C4 genes: Ancient duplication and conservation during jawed vertebrate evolution" @default.
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- W2555823385 doi "https://doi.org/10.1016/j.dci.2016.11.009" @default.
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