FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555870129> ?p ?o ?g. }

• W2555870129 abstract "Background Giant Cell Arteritis (GCA) is a common vasculitis with significant risk of blindness. Although temporal artery biopsy (TAB) is currently performed for diagnosis, the sensitivity can be as low as 39%; ultrasound is emerging as a more effective and cheaper test. Vascular endothelial growth factor (VEGF) is present in inflamed arterial wall in GCA and elevated circulating levels have been reported in GCA compared to controls. Measurement of VEGF is less invasive than TAB, and cheaper than TAB or ultrasound. Objectives 1) Analyse performance of VEGF as a diagnostic marker for GCA 2) Combine VEGF with ESR and CRP to assess performance 3) Assess local expression of VEGF in TAB Methods We used samples from patients recruited to a large multi-centre study comparing temporal artery biopsy with ultrasound for diagnosis of suspected giant cell arteritis. We randomly selected 26 patients with TAB-positive GCA and 26 controls (negative TAB and final diagnosis not GCA). Most patients were receiving high doses of glucocorticoid therapy at recruitment. Serum VEGF concentration was measured at weeks 0, 2 and 26 by ELISA (Quantikine R&D systems). Week 0 values were plotted on a Receiver Operating Characteristic (ROC) curve to identify the most effective cut-off for an abnormal result. Sections of TAB were stained by immunohistochemistry for VEGF expression (Polyclonal Rabbit anti-human VEGF, AbCAM). Results Patients were significantly older than controls (mean age 76 SD 7.3 vs 66 SD 11.3, p=0.003). but had similar gender (62% females each). The mean (95% CI) baseline VEGF concentration was 873 pg/ml (631–1110) in GCA vs 476 pg/ml [328–625] in controls (p=0.017). This difference between groups was not observed at any other timepoint. The area under the ROC curve for VEGF concentration at week 0 was 0.73. The optimal cut off was 713pg/ml, providing a sensitivity of 65% and a specificity of 88%. These values compare favourably with reported performance of other available tests such as ESR and CRP (sensitivity 86% and 84%; specificity 30% and 29% respectively), TAB (sensitivity 40%, specificity 100%), and ultrasound (sensitivity 54%, specificity 81%). VEGF concentration was combined with ESR and CRP values to assess if this improved its performance. High ESR was defined as ≥22 in men, ≥29 in women, and high CRP was ≥8. These results are summarised in Figure 1. ESR+CRP LOW had a 94% Negative predictive value to exclude GCA. ESR/CRP High + VEGF High had 95% Positive predictive value to diagnose GCA. For 27% of patients a further diagnostic test is needed. VEGF expression by immunohistochemistry in TAB sections from 3 patients with GCA was higher than 2 controls, implying that VEGF is upregulated in GCA and may signal locally to drive the vasculitic process. Furthermore, serum concentration appears to reflect local concentration in the temporal artery; therefore measuring serum VEGF concentration is a valid surrogate for local inflammation. Conclusions In this study, serum VEGF was a useful test to support a diagnosis of GCA and potentially avoid the cost of TAB or ultrasound in over 60% of patients. Further studies will evaluate this in a larger cohort of suspected cases of GCA. Furthermore, VEGF could potentially be effective as a prognostic marker, or as a therapeutic target. Disclosure of Interest None declared" @default.
• W2555870129 created "2016-11-30" @default.
• W2555870129 creator A5017331418 @default.
• W2555870129 creator A5017685513 @default.
• W2555870129 creator A5018778475 @default.
• W2555870129 creator A5020834825 @default.
• W2555870129 creator A5030577320 @default.
• W2555870129 creator A5044577690 @default.
• W2555870129 creator A5056644392 @default.
• W2555870129 creator A5068750397 @default.
• W2555870129 creator A5085691562 @default.
• W2555870129 creator A5087968638 @default.
• W2555870129 creator A5089200638 @default.
• W2555870129 date "2016-06-01" @default.
• W2555870129 modified "2023-09-22" @default.
• W2555870129 title "FRI0028 Vascular Endothelial Growth Factor as An Aid To Diagnosis of Giant Cell Arteritis" @default.
• W2555870129 doi "https://doi.org/10.1136/annrheumdis-2016-eular.1319" @default.
• W2555870129 hasPublicationYear "2016" @default.
• W2555870129 type Work @default.
• W2555870129 sameAs 2555870129 @default.
• W2555870129 citedByCount "0" @default.
• W2555870129 crossrefType "journal-article" @default.
• W2555870129 hasAuthorship W2555870129A5017331418 @default.
• W2555870129 hasAuthorship W2555870129A5017685513 @default.
• W2555870129 hasAuthorship W2555870129A5018778475 @default.
• W2555870129 hasAuthorship W2555870129A5020834825 @default.
• W2555870129 hasAuthorship W2555870129A5030577320 @default.
• W2555870129 hasAuthorship W2555870129A5044577690 @default.
• W2555870129 hasAuthorship W2555870129A5056644392 @default.
• W2555870129 hasAuthorship W2555870129A5068750397 @default.
• W2555870129 hasAuthorship W2555870129A5085691562 @default.
• W2555870129 hasAuthorship W2555870129A5087968638 @default.
• W2555870129 hasAuthorship W2555870129A5089200638 @default.
• W2555870129 hasConcept C126322002 @default.
• W2555870129 hasConcept C126894567 @default.
• W2555870129 hasConcept C142724271 @default.
• W2555870129 hasConcept C167734588 @default.
• W2555870129 hasConcept C204232928 @default.
• W2555870129 hasConcept C2775934546 @default.
• W2555870129 hasConcept C2776015282 @default.
• W2555870129 hasConcept C2776712624 @default.
• W2555870129 hasConcept C2777025900 @default.
• W2555870129 hasConcept C2779134260 @default.
• W2555870129 hasConcept C2781343717 @default.
• W2555870129 hasConcept C58471807 @default.
• W2555870129 hasConcept C71924100 @default.
• W2555870129 hasConcept C90924648 @default.
• W2555870129 hasConceptScore W2555870129C126322002 @default.
• W2555870129 hasConceptScore W2555870129C126894567 @default.
• W2555870129 hasConceptScore W2555870129C142724271 @default.
• W2555870129 hasConceptScore W2555870129C167734588 @default.
• W2555870129 hasConceptScore W2555870129C204232928 @default.
• W2555870129 hasConceptScore W2555870129C2775934546 @default.
• W2555870129 hasConceptScore W2555870129C2776015282 @default.
• W2555870129 hasConceptScore W2555870129C2776712624 @default.
• W2555870129 hasConceptScore W2555870129C2777025900 @default.
• W2555870129 hasConceptScore W2555870129C2779134260 @default.
• W2555870129 hasConceptScore W2555870129C2781343717 @default.
• W2555870129 hasConceptScore W2555870129C58471807 @default.
• W2555870129 hasConceptScore W2555870129C71924100 @default.
• W2555870129 hasConceptScore W2555870129C90924648 @default.
• W2555870129 hasLocation W25558701291 @default.
• W2555870129 hasOpenAccess W2555870129 @default.
• W2555870129 hasPrimaryLocation W25558701291 @default.
• W2555870129 hasRelatedWork W1584199165 @default.
• W2555870129 hasRelatedWork W2100586657 @default.
• W2555870129 hasRelatedWork W2140438641 @default.
• W2555870129 hasRelatedWork W2163199691 @default.
• W2555870129 hasRelatedWork W2188208267 @default.
• W2555870129 hasRelatedWork W2330414892 @default.
• W2555870129 hasRelatedWork W2347391908 @default.
• W2555870129 hasRelatedWork W2354837707 @default.
• W2555870129 hasRelatedWork W2380354314 @default.
• W2555870129 hasRelatedWork W2403831157 @default.
• W2555870129 hasRelatedWork W2528829495 @default.
• W2555870129 hasRelatedWork W2580136906 @default.
• W2555870129 hasRelatedWork W2754505400 @default.
• W2555870129 hasRelatedWork W2755055803 @default.
• W2555870129 hasRelatedWork W2920194096 @default.
• W2555870129 hasRelatedWork W2947638359 @default.
• W2555870129 hasRelatedWork W2975480263 @default.
• W2555870129 hasRelatedWork W3032248630 @default.
• W2555870129 hasRelatedWork W3087540549 @default.
• W2555870129 hasRelatedWork W3198320121 @default.
• W2555870129 isParatext "false" @default.
• W2555870129 isRetracted "false" @default.
• W2555870129 magId "2555870129" @default.
• W2555870129 workType "article" @default.