Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555874338> ?p ?o ?g. }
- W2555874338 abstract "BACKGROUND: The incidence of all forms of congenital heart defects is 0.75%. For patients with congenital heart defects, life-expectancy has improved with new treatment modalities. Structural heart defects may require surgical or catheter treatment which may be corrective or palliative. Even those with corrective therapy need regular follow-up due to residual lesions, late sequelae, and possible complications after interventions. AIMS: The aim of this thesis was to evaluate cardiac function before and after treatment for volume overload of the right ventricle (RV) caused by atrial septal defect (ASD), volume overload of the left ventricle (LV) caused by patent ductus arteriosus (PDA), and pressure overload of the LV caused by coarctation of the aorta (CoA), and to evaluate cardiac function in patients with Mulibrey nanism. METHODS: In Study I, of the 24 children with ASD, 7 underwent surgical correction and 17 percutaneous occlusion of ASD. Study II had 33 patients with PDA undergoing percutaneous occlusion. In Study III, 28 patients with CoA underwent either surgical correction or percutaneous balloon dilatation of CoA. Study IV comprised 26 children with Mulibrey nanism. A total of 76 healthy voluntary children were examined as a control group. In each study, controls were matched to patients. All patients and controls underwent clinical cardiovascular examinations, twodimensional (2D) and three-dimensional (3D) echocardiographic examinations, and blood sampling for measurement of natriuretic peptides prior to the intervention and twice or three times thereafter. Control children were examined once by 2D and 3D echocardiography. M-mode echocardiography was performed from the parasternal long axis view directed by 2D echocardiography. The left atrium-to-aorta (LA/Ao) ratio was calculated as an index of LA size. The end-diastolic and endsystolic dimensions of LV as well as the end-diastolic thicknesses of the interventricular septum and LV posterior wall were measured. LV volumes, and the fractional shortening (FS) and ejection fraction (EF) as indices of contractility were then calculated, and the z scores of LV dimensions determined. Diastolic function of LV was estimated from the mitral inflow signal obtained by Doppler echocardiography. In three-dimensional echocardiography, time-volume curves were used to determine end-diastolic and end-systolic volumes, stroke volume, and EF. Diastolic and systolic function of LV was estimated from the calculated first derivatives of these curves. RESULTS: (I): In all children with ASD, during the one-year follow-up, the z score of the RV enddiastolic diameter decreased and that of LV increased. However, dilatation of RV did not resolve entirely during the follow-up in either treatment group. In addition, the size of LV increased more slowly in the surgical subgroup but reached control levels in both groups. Concentrations of natriuretic peptides in patients treated percutaneously increased during the first month after ASD closure and normalized thereafter, but in patients treated surgically, they remained higher than in controls. (II): In the PDA group, at baseline, the end-diastolic diameter of LV measured over 2SD in 5 of 33 patients. The median N-terminal pro-brain natriuretic peptide (proBNP) concentration before closure measured 72 ng/l in the control group and 141 ng/l in the PDA group (P = 0.001) and 6 months after closure measured 78.5 ng/l (P = NS). Patients differed from control subjects in indices of LV diastolic and systolic function at baseline, but by the end of follow-up, all these differences had disappeared. Even in the subgroup of patients with normal-sized LV at baseline, the LV end-diastolic volume decreased significantly during follow-up. (III): Before repair, the size and wall thickness of LV were higher in patients with CoA than in controls. Systolic blood pressure measured a median 123 mm Hg in patients before repair (P < 0.001) and 103 mm Hg one year thereafter, and 101 mm Hg in controls. The diameter of the coarctation segment measured a median 3.0 mm at baseline, and 7.9 at the 12-month (P = 0.006) follow-up. Thicknesses of the interventricular septum and posterior wall of the LV decreased after repair but increased to the initial level one year thereafter. The velocity time integrals of mitral inflow increased, but no changes were evident in LV dimensions or contractility. During follow-up, serum levels of natriuretic peptides decreased correlating with diastolic and systolic indices of LV function in 2D" @default.
- W2555874338 created "2016-11-30" @default.
- W2555874338 creator A5083133533 @default.
- W2555874338 date "2007-01-01" @default.
- W2555874338 modified "2023-09-27" @default.
- W2555874338 title "Cardiac function before and after treatment for various types of loading conditions and in myocardial restriction" @default.
- W2555874338 cites W108236244 @default.
- W2555874338 cites W127288233 @default.
- W2555874338 cites W1485698606 @default.
- W2555874338 cites W1492485651 @default.
- W2555874338 cites W1498780963 @default.
- W2555874338 cites W1525631176 @default.
- W2555874338 cites W1527110150 @default.
- W2555874338 cites W1542820946 @default.
- W2555874338 cites W1594171378 @default.
- W2555874338 cites W1597964526 @default.
- W2555874338 cites W1599321856 @default.
- W2555874338 cites W1599334180 @default.
- W2555874338 cites W16620245 @default.
- W2555874338 cites W169208914 @default.
- W2555874338 cites W1915398350 @default.
- W2555874338 cites W1964816689 @default.
- W2555874338 cites W1964997635 @default.
- W2555874338 cites W1965125061 @default.
- W2555874338 cites W1965540244 @default.
- W2555874338 cites W1966190799 @default.
- W2555874338 cites W1966916441 @default.
- W2555874338 cites W1968808677 @default.
- W2555874338 cites W1968985622 @default.
- W2555874338 cites W1969488920 @default.
- W2555874338 cites W1969923946 @default.
- W2555874338 cites W1970060638 @default.
- W2555874338 cites W1970359223 @default.
- W2555874338 cites W1970781680 @default.
- W2555874338 cites W1971899434 @default.
- W2555874338 cites W1972407675 @default.
- W2555874338 cites W1973783683 @default.
- W2555874338 cites W1974315289 @default.
- W2555874338 cites W1974498420 @default.
- W2555874338 cites W1974527466 @default.
- W2555874338 cites W1975208970 @default.
- W2555874338 cites W1975857988 @default.
- W2555874338 cites W1976185738 @default.
- W2555874338 cites W1977201081 @default.
- W2555874338 cites W1977272180 @default.
- W2555874338 cites W1977898160 @default.
- W2555874338 cites W1978632222 @default.
- W2555874338 cites W1979962365 @default.
- W2555874338 cites W1980781774 @default.
- W2555874338 cites W1980879874 @default.
- W2555874338 cites W1981344257 @default.
- W2555874338 cites W1982794805 @default.
- W2555874338 cites W1982951043 @default.
- W2555874338 cites W1984104934 @default.
- W2555874338 cites W1985452995 @default.
- W2555874338 cites W1985982734 @default.
- W2555874338 cites W1987060011 @default.
- W2555874338 cites W1987735170 @default.
- W2555874338 cites W1988689295 @default.
- W2555874338 cites W1990065600 @default.
- W2555874338 cites W1991159407 @default.
- W2555874338 cites W1991472724 @default.
- W2555874338 cites W1991513788 @default.
- W2555874338 cites W1991534965 @default.
- W2555874338 cites W1993246612 @default.
- W2555874338 cites W1993307006 @default.
- W2555874338 cites W1993663106 @default.
- W2555874338 cites W1993912318 @default.
- W2555874338 cites W1994433151 @default.
- W2555874338 cites W1994756266 @default.
- W2555874338 cites W1994855172 @default.
- W2555874338 cites W1995507609 @default.
- W2555874338 cites W1995600248 @default.
- W2555874338 cites W1997351760 @default.
- W2555874338 cites W1997478551 @default.
- W2555874338 cites W1998093200 @default.
- W2555874338 cites W1998108470 @default.
- W2555874338 cites W1998171629 @default.
- W2555874338 cites W1998543719 @default.
- W2555874338 cites W1999712109 @default.
- W2555874338 cites W2000678349 @default.
- W2555874338 cites W2000869637 @default.
- W2555874338 cites W2001315339 @default.
- W2555874338 cites W2001401679 @default.
- W2555874338 cites W2002582264 @default.
- W2555874338 cites W2002769481 @default.
- W2555874338 cites W2003363390 @default.
- W2555874338 cites W2004042745 @default.
- W2555874338 cites W2004649896 @default.
- W2555874338 cites W2005430565 @default.
- W2555874338 cites W2005666155 @default.
- W2555874338 cites W2005682185 @default.
- W2555874338 cites W2006137562 @default.
- W2555874338 cites W2006950429 @default.
- W2555874338 cites W2007552399 @default.
- W2555874338 cites W2008220576 @default.
- W2555874338 cites W2008564184 @default.
- W2555874338 cites W2008701985 @default.
- W2555874338 cites W2009043475 @default.
- W2555874338 cites W2009238054 @default.