Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555876690> ?p ?o ?g. }
- W2555876690 endingPage "186" @default.
- W2555876690 startingPage "180" @default.
- W2555876690 abstract "Background: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. Hypothesis: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. Methods: Seven rats received radiation (12 Gy) to both cochleae. In irradiated rats and six nonirradiated rats, IT DXM was randomized to one ear, while tympanic puncture without DXM was performed on the contralateral ear. Baseline and 4-week postradiation auditory-evoked potential tests were performed. The cochleae were processed for HC viability. Results: Cochleae exposed to radiation demonstrated more outer HC (OHC) loss in all turns than nonirradiated ears ( p <0.05). OHCs were more susceptible to radiation injury than inner HCs in the middle and basal turns ( p <0.05). In irradiated cochleae, there was a nonsignificant trend for less OHC loss with IT DXM in the basal turn when compared with placebo. IT DXM did not improve radiation-induced hearing threshold shifts; however, a high rate of tympanic membrane perforations occurred with irradiated ears which may contribute to this finding. Conclusion: Radiation induced loss of OHCs in all turns of the cochlea. IT DXM reduced OHC loss in the basal turn of irradiated ears; however, this finding did not achieve statistical significance. Although IT DXM did not affect radiation-induced hearing threshold shifts in adult rats in vivo, this may be due to a high rate of tympanic membrane perforations." @default.
- W2555876690 created "2016-11-30" @default.
- W2555876690 creator A5014026286 @default.
- W2555876690 creator A5022198589 @default.
- W2555876690 creator A5030458072 @default.
- W2555876690 creator A5030912475 @default.
- W2555876690 creator A5047246441 @default.
- W2555876690 creator A5053247003 @default.
- W2555876690 creator A5055557790 @default.
- W2555876690 creator A5069399364 @default.
- W2555876690 creator A5075874364 @default.
- W2555876690 creator A5090093877 @default.
- W2555876690 date "2017-02-01" @default.
- W2555876690 modified "2023-10-18" @default.
- W2555876690 title "Effects of Intratympanic Dexamethasone on High-Dose Radiation Ototoxicity In Vivo" @default.
- W2555876690 cites W1487336579 @default.
- W2555876690 cites W1971747664 @default.
- W2555876690 cites W1975177376 @default.
- W2555876690 cites W2004378835 @default.
- W2555876690 cites W2007188602 @default.
- W2555876690 cites W2007911882 @default.
- W2555876690 cites W2012013075 @default.
- W2555876690 cites W2018895767 @default.
- W2555876690 cites W2025588456 @default.
- W2555876690 cites W2026131820 @default.
- W2555876690 cites W2026377273 @default.
- W2555876690 cites W2027029724 @default.
- W2555876690 cites W2034920601 @default.
- W2555876690 cites W2058257534 @default.
- W2555876690 cites W2061137918 @default.
- W2555876690 cites W2077152987 @default.
- W2555876690 cites W2078291178 @default.
- W2555876690 cites W2079265161 @default.
- W2555876690 cites W2091001607 @default.
- W2555876690 cites W2105296692 @default.
- W2555876690 cites W2108152761 @default.
- W2555876690 cites W2126762891 @default.
- W2555876690 cites W2129299671 @default.
- W2555876690 cites W2136977414 @default.
- W2555876690 cites W2144204436 @default.
- W2555876690 cites W2146373235 @default.
- W2555876690 cites W2147953824 @default.
- W2555876690 cites W2149669698 @default.
- W2555876690 cites W21553284 @default.
- W2555876690 cites W2159274932 @default.
- W2555876690 cites W2164157068 @default.
- W2555876690 cites W2176690649 @default.
- W2555876690 cites W2185182290 @default.
- W2555876690 cites W2233496256 @default.
- W2555876690 cites W2275534944 @default.
- W2555876690 cites W2374292206 @default.
- W2555876690 cites W918937935 @default.
- W2555876690 doi "https://doi.org/10.1097/mao.0000000000001289" @default.
- W2555876690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27898607" @default.
- W2555876690 hasPublicationYear "2017" @default.
- W2555876690 type Work @default.
- W2555876690 sameAs 2555876690 @default.
- W2555876690 citedByCount "5" @default.
- W2555876690 countsByYear W25558766902019 @default.
- W2555876690 countsByYear W25558766902020 @default.
- W2555876690 countsByYear W25558766902023 @default.
- W2555876690 crossrefType "journal-article" @default.
- W2555876690 hasAuthorship W2555876690A5014026286 @default.
- W2555876690 hasAuthorship W2555876690A5022198589 @default.
- W2555876690 hasAuthorship W2555876690A5030458072 @default.
- W2555876690 hasAuthorship W2555876690A5030912475 @default.
- W2555876690 hasAuthorship W2555876690A5047246441 @default.
- W2555876690 hasAuthorship W2555876690A5053247003 @default.
- W2555876690 hasAuthorship W2555876690A5055557790 @default.
- W2555876690 hasAuthorship W2555876690A5069399364 @default.
- W2555876690 hasAuthorship W2555876690A5075874364 @default.
- W2555876690 hasAuthorship W2555876690A5090093877 @default.
- W2555876690 hasConcept C105702510 @default.
- W2555876690 hasConcept C126322002 @default.
- W2555876690 hasConcept C150903083 @default.
- W2555876690 hasConcept C207001950 @default.
- W2555876690 hasConcept C2776694085 @default.
- W2555876690 hasConcept C2778024521 @default.
- W2555876690 hasConcept C2778239845 @default.
- W2555876690 hasConcept C2778534666 @default.
- W2555876690 hasConcept C2779306644 @default.
- W2555876690 hasConcept C2780130748 @default.
- W2555876690 hasConcept C2780401358 @default.
- W2555876690 hasConcept C2780493683 @default.
- W2555876690 hasConcept C2989005 @default.
- W2555876690 hasConcept C548259974 @default.
- W2555876690 hasConcept C71924100 @default.
- W2555876690 hasConcept C86803240 @default.
- W2555876690 hasConceptScore W2555876690C105702510 @default.
- W2555876690 hasConceptScore W2555876690C126322002 @default.
- W2555876690 hasConceptScore W2555876690C150903083 @default.
- W2555876690 hasConceptScore W2555876690C207001950 @default.
- W2555876690 hasConceptScore W2555876690C2776694085 @default.
- W2555876690 hasConceptScore W2555876690C2778024521 @default.
- W2555876690 hasConceptScore W2555876690C2778239845 @default.
- W2555876690 hasConceptScore W2555876690C2778534666 @default.
- W2555876690 hasConceptScore W2555876690C2779306644 @default.
- W2555876690 hasConceptScore W2555876690C2780130748 @default.