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- W2555882095 abstract "Antioxidant and cytotoxic activities of Achillea millefolium were investigated in this study. The cytotoxic effect of methanol and chloroform extracts of A. millefolium against four human cancer cell lines: breast (MCF-7), leukemia (THP-1), prostate (PC-3) and ovarian (OVCAR-5) was evaluated using Sulpharhodamine B (SRB) assay. The antioxidant activity of the extracts was determined using two assay systems: 2, 2-dipheny-1-picryl hydrazyl (DPPH) and 2, 2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) assays and that of chemical constituents was evaluated using DPPH assay. All the extracts exhibited broad spectrum cytotoxicity against all the four investigated cancer cell lines with chloroform extract of aerial part of A. millefolium (AMRC) showing growth inhibition of 99%, 98% and 99% against THP, MCF-7 and OVCAR-5 cell lines at 50 µg/mL concentration. All the six extracts and isolated constituents were screened for antioxidant activity and exhibited dose dependent antioxidant activity. AMRC, quercetin and dihydroquercetin showed the best results with IC50 of 2.5, 2.2 and 2.26 µg/mL respectively." @default.
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- W2555882095 date "2014-01-01" @default.
- W2555882095 modified "2023-09-27" @default.
- W2555882095 title "Antioxidant and Cytotoxic Activities of Achillea millefolium from Kashmir" @default.
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