FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555883478> ?p ?o ?g. }

• W2555883478 endingPage "261" @default.
• W2555883478 startingPage "255" @default.
• W2555883478 abstract "Lapses in the prevention of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) warrant novel approaches. Such approaches include, among others, the use of post-transplantation cyclophosphamide (PTC) and proteasome inhibitors. Although PTC alone consistently produces low rates of chronic GVHD, the incidence of acute GVHD remains significant. Inversely, prolonged post-transplantation administration of proteasome inhibitors carries a risk of paradoxical aggravation of GVHD. We examined whether the combination of cyclophosphamide and ixazomib addresses the limitations of each of these agents when used alone to prevent GVHD in mice subjected to allogeneic HSCT across MHC barriers. We chose ixazomib, an orally bioavailable proteasome inhibitor, because of its favorable physiochemical characteristics. The combination of cyclophosphamide and ixazomib improved overall survival of mice in comparison to an untreated control group and to groups receiving either cyclophosphamide alone or ixazomib alone. Furthermore, cyclophosphamide prevented the surge of IL-1β, GVHD aggravation, and sudden death associated with prolonged administration of ixazomib after HSCT. Finally, we demonstrated that although ixazomib was administered before cyclophosphamide, it did not impair the preferential depletion of proliferating as opposed to resting donor T cells. Our data suggest that the combination of cyclophosphamide and ixazomib for the prevention of GVHD after allogeneic HSCT is promising and merits further investigation in clinical trials." @default.
• W2555883478 created "2016-11-30" @default.
• W2555883478 creator A5019509968 @default.
• W2555883478 creator A5022609520 @default.
• W2555883478 creator A5052770467 @default.
• W2555883478 creator A5057695779 @default.
• W2555883478 creator A5066453547 @default.
• W2555883478 creator A5081036799 @default.
• W2555883478 creator A5091902341 @default.
• W2555883478 date "2017-02-01" @default.
• W2555883478 modified "2023-09-25" @default.
• W2555883478 title "Post-Transplantation Cyclophosphamide and Ixazomib Combination Rescues Mice Subjected to Experimental Graft-versus-Host Disease and Is Superior to Either Agent Alone" @default.
• W2555883478 cites W1502924554 @default.
• W2555883478 cites W1648827754 @default.
• W2555883478 cites W1968856388 @default.
• W2555883478 cites W1976063914 @default.
• W2555883478 cites W1982767302 @default.
• W2555883478 cites W1999131167 @default.
• W2555883478 cites W2003407014 @default.
• W2555883478 cites W2006427551 @default.
• W2555883478 cites W2020725971 @default.
• W2555883478 cites W2030428868 @default.
• W2555883478 cites W2041380049 @default.
• W2555883478 cites W2044516114 @default.
• W2555883478 cites W2054671000 @default.
• W2555883478 cites W2055553511 @default.
• W2555883478 cites W2064504273 @default.
• W2555883478 cites W2066886754 @default.
• W2555883478 cites W2098739235 @default.
• W2555883478 cites W2099261151 @default.
• W2555883478 cites W2109371953 @default.
• W2555883478 cites W2126724696 @default.
• W2555883478 cites W2157325100 @default.
• W2555883478 cites W2169530433 @default.
• W2555883478 cites W2171005667 @default.
• W2555883478 cites W2234309584 @default.
• W2555883478 cites W2321365245 @default.
• W2555883478 cites W2400645104 @default.
• W2555883478 cites W2490433371 @default.
• W2555883478 cites W4233066604 @default.
• W2555883478 doi "https://doi.org/10.1016/j.bbmt.2016.11.015" @default.
• W2555883478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27888016" @default.
• W2555883478 hasPublicationYear "2017" @default.
• W2555883478 type Work @default.
• W2555883478 sameAs 2555883478 @default.
• W2555883478 citedByCount "12" @default.
• W2555883478 countsByYear W25558834782017 @default.
• W2555883478 countsByYear W25558834782018 @default.
• W2555883478 countsByYear W25558834782019 @default.
• W2555883478 countsByYear W25558834782020 @default.
• W2555883478 countsByYear W25558834782021 @default.
• W2555883478 countsByYear W25558834782022 @default.
• W2555883478 crossrefType "journal-article" @default.
• W2555883478 hasAuthorship W2555883478A5019509968 @default.
• W2555883478 hasAuthorship W2555883478A5022609520 @default.
• W2555883478 hasAuthorship W2555883478A5052770467 @default.
• W2555883478 hasAuthorship W2555883478A5057695779 @default.
• W2555883478 hasAuthorship W2555883478A5066453547 @default.
• W2555883478 hasAuthorship W2555883478A5081036799 @default.
• W2555883478 hasAuthorship W2555883478A5091902341 @default.
• W2555883478 hasBestOaLocation W25558834781 @default.
• W2555883478 hasConcept C126322002 @default.
• W2555883478 hasConcept C203014093 @default.
• W2555883478 hasConcept C2776364478 @default.
• W2555883478 hasConcept C2776694085 @default.
• W2555883478 hasConcept C2776755627 @default.
• W2555883478 hasConcept C2777408962 @default.
• W2555883478 hasConcept C2778367456 @default.
• W2555883478 hasConcept C2779972918 @default.
• W2555883478 hasConcept C2780108899 @default.
• W2555883478 hasConcept C2781098529 @default.
• W2555883478 hasConcept C2911091166 @default.
• W2555883478 hasConcept C71924100 @default.
• W2555883478 hasConcept C98274493 @default.
• W2555883478 hasConceptScore W2555883478C126322002 @default.
• W2555883478 hasConceptScore W2555883478C203014093 @default.
• W2555883478 hasConceptScore W2555883478C2776364478 @default.
• W2555883478 hasConceptScore W2555883478C2776694085 @default.
• W2555883478 hasConceptScore W2555883478C2776755627 @default.
• W2555883478 hasConceptScore W2555883478C2777408962 @default.
• W2555883478 hasConceptScore W2555883478C2778367456 @default.
• W2555883478 hasConceptScore W2555883478C2779972918 @default.
• W2555883478 hasConceptScore W2555883478C2780108899 @default.
• W2555883478 hasConceptScore W2555883478C2781098529 @default.
• W2555883478 hasConceptScore W2555883478C2911091166 @default.
• W2555883478 hasConceptScore W2555883478C71924100 @default.
• W2555883478 hasConceptScore W2555883478C98274493 @default.
• W2555883478 hasIssue "2" @default.
• W2555883478 hasLocation W25558834781 @default.
• W2555883478 hasLocation W25558834782 @default.
• W2555883478 hasLocation W25558834783 @default.
• W2555883478 hasOpenAccess W2555883478 @default.
• W2555883478 hasPrimaryLocation W25558834781 @default.
• W2555883478 hasRelatedWork W1994968709 @default.
• W2555883478 hasRelatedWork W2052860239 @default.
• W2555883478 hasRelatedWork W2126348857 @default.
• W2555883478 hasRelatedWork W2522420753 @default.
• W2555883478 hasRelatedWork W2555883478 @default.

• next