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- W255588476 abstract "Cancer is the result of a disturbed biological equilibrium that results in uncontrolled proliferation of malignant cells accompanied by invasion and destruction of surrounding normal tissue. Tumorigenesis is initiated by genetic susceptibility (DNA mutation inherited from parents), epigenetic influences (environmental stimuli to which the organism is exposed), or a combination of both. As the tumor develops over time, additional mutations are acquired in the genome that lead to increasingly aggressive behavior. However, it is important to note that, in addition to the molecular alterations that occur in the malignant cells, the process of tumor progression is also significantly influenced by tumor—host cell interactions. There is a body of literature that supports the critical importance of stromal and other host cells in the development of cancer (1–6). Investigators who are interested in determining the mechanisms that underlie tumor progression in vivo must be aware of and account for the role that each individual cell type plays in the process. Therefore, depending on the goals of the study, it may be important to select methodologies that permit selective analysis of both normal and neoplastic cells." @default.
- W255588476 created "2016-06-24" @default.
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- W255588476 date "2003-01-01" @default.
- W255588476 modified "2023-09-25" @default.
- W255588476 title "Proteomic Profiling of the Cancer Microenvironment" @default.
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- W255588476 doi "https://doi.org/10.1007/978-1-59259-414-6_21" @default.
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