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- W2555901230 abstract "Background The number of clinical SpA-features plays an important role in the Assessment of SpondyloArthritis international Society (ASAS) modified Berlin algorithm for the diagnostic work-up of patients (pts) with a suspicion of axial SpA (axSpA). Objectives To investigate whether all pts with short duration chronic back pain (CBP) and multiple SpA-features are always diagnosed as axSpA by the rheumatologist and to describe the features of these patients. Methods The SPondyloArthritis Caught Early (SPACE)-cohort includes CBP pts (≥3 months, ≤2 years, onset Results A total of 522 pts were analysed in this study: before sacroiliac imaging and HLA-B27 testing 164/522 (31.4%) pts had no or 1 SpA-feature, 148/522 (28.4%) pts had 2 SpA-features, 85/522 (16.3%) pts had 3 SpA-features, and 125/522 (23.9%) pts had ≥4 SpA-features respectively. IBP, good response to NSAIDs, and positive family history for SpA were most common in all subgroups (0 or 1 feature: 26.8%, 8.5%, and 16.5% of pts; 2 features: 72.3%, 34.5%, 39.9%; 3 features: 87.1%, 60.0%, 54.1%; ≥4 features: 94.4%, 83.2%, 68.0% respectively). Of the pts with 2 and 3 SpA-features with negative X-SI 20/132 (15.2%) and 9/78 (11.5%) did not have axSpA diagnosis despite being HLA-B27+ (Figure 1). All pts with ≥4 SpA-features and X-SI+ (n=28) were diagnosed with axSpA. In contrast to what would be expected by following the modified Berlin algorithm for pts with ≥4 SpA-features, 18/94 pts (19.1%) with negative imaging (of which 4 HLA-B27+), were not diagnosed with axSpA by their rheumatologist. Multivariate regression analysis of presence of SpA-features identified MRI-SI+ (OR 41.7;95%CI 17.3.1–100.5), X-SI+ (OR 31.5;95%CI 3.1–321.0), HLA-B27+ (OR 4.7;95%CI 2.5–8.6), uveitis (OR 4.3;95%CI 1.5–12.7), IBP (OR 2.5;95%CI 1.4–4.7), heel enthesitis (OR 5.5;95%CI 2.7–11.4), IBD (OR 3.2;95%CI 1.2–8.8), elevated CRP/ESR (OR 2.7;95%CI 1.4–5.3), and psoriasis (OR 2.5;95%CI 1.0–6.0) as significant independent predictors of axSpA diagnosis. Conclusions In this cohort of pts with CBP having numerous SpA-features did not automatically lead to a clinical axSpA diagnosis but positive imaging was the main driving factor to diagnosis of axSpA. Disclosure of Interest None declared" @default.
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- W2555901230 date "2016-06-01" @default.
- W2555901230 modified "2023-10-17" @default.
- W2555901230 title "OP0085 Does The Presence of Multiple SpA-Features in Patients with Chronic Back Pain Always Lead To Diagnosis of Axial Spondyloarthritis?" @default.
- W2555901230 doi "https://doi.org/10.1136/annrheumdis-2016-eular.2707" @default.
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