FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2555932761> ?p ?o ?g. }

• W2555932761 abstract "Post-ischemic activation of NMDA receptors (NMDARs) has been linked to NMDAR subunit-specific signaling that mediates pro-survival or pro-death activity. Although extensive studies have been performed to characterize the role of GluN2A and GluN2B following ischemia, there is less understanding regarding the regulation of GluN2C. Here, we show that GluN2C expression is increased in acute hippocampal slices in response to ischemia. Strikingly, GluN2C knockout mice, following global cerebral ischemia, exhibit greater neuronal death in the CA1 area of the hippocampus and reduced spatial working memory compared to wild-type mice. Moreover, we find that GluN2C-expressing hippocampal neurons show marked resistance to NMDA-induced toxicity and reduced calcium influx. Using both in vivo and in vitro experimental models of ischemia, we demonstrate a neuroprotective role of GluN2C, suggesting a mechanism by which GluN2C is upregulated to promote neuronal survival following ischemia. These results may provide insights into development of NMDAR subunit-specific therapeutic strategies to protect neurons from excitotoxicity." @default.
• W2555932761 created "2016-11-30" @default.
• W2555932761 creator A5001850476 @default.
• W2555932761 creator A5007165393 @default.
• W2555932761 creator A5007656302 @default.
• W2555932761 creator A5036246760 @default.
• W2555932761 creator A5069453585 @default.
• W2555932761 creator A5072775773 @default.
• W2555932761 creator A5075986086 @default.
• W2555932761 date "2016-11-15" @default.
• W2555932761 modified "2023-10-12" @default.
• W2555932761 title "Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia" @default.
• W2555932761 cites W1500409864 @default.
• W2555932761 cites W1551983009 @default.
• W2555932761 cites W1918304474 @default.
• W2555932761 cites W1957958801 @default.
• W2555932761 cites W1966037459 @default.
• W2555932761 cites W1969083970 @default.
• W2555932761 cites W1976916297 @default.
• W2555932761 cites W1978542087 @default.
• W2555932761 cites W1979987497 @default.
• W2555932761 cites W1982003826 @default.
• W2555932761 cites W1994732950 @default.
• W2555932761 cites W2002190647 @default.
• W2555932761 cites W2006514144 @default.
• W2555932761 cites W2007018052 @default.
• W2555932761 cites W2016166286 @default.
• W2555932761 cites W2024380057 @default.
• W2555932761 cites W2025809696 @default.
• W2555932761 cites W2027625804 @default.
• W2555932761 cites W2029972861 @default.
• W2555932761 cites W2037852973 @default.
• W2555932761 cites W2038590075 @default.
• W2555932761 cites W2048537000 @default.
• W2555932761 cites W2063536602 @default.
• W2555932761 cites W2064310011 @default.
• W2555932761 cites W2065169750 @default.
• W2555932761 cites W2078167209 @default.
• W2555932761 cites W2082791664 @default.
• W2555932761 cites W2084627991 @default.
• W2555932761 cites W2087824537 @default.
• W2555932761 cites W2089131634 @default.
• W2555932761 cites W2097095684 @default.
• W2555932761 cites W2099311604 @default.
• W2555932761 cites W2106977035 @default.
• W2555932761 cites W2139748951 @default.
• W2555932761 cites W2180920467 @default.
• W2555932761 cites W4319425380 @default.
• W2555932761 doi "https://doi.org/10.1038/srep37033" @default.
• W2555932761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5109474" @default.
• W2555932761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27845401" @default.
• W2555932761 hasPublicationYear "2016" @default.
• W2555932761 type Work @default.
• W2555932761 sameAs 2555932761 @default.
• W2555932761 citedByCount "20" @default.
• W2555932761 countsByYear W25559327612017 @default.
• W2555932761 countsByYear W25559327612018 @default.
• W2555932761 countsByYear W25559327612019 @default.
• W2555932761 countsByYear W25559327612020 @default.
• W2555932761 countsByYear W25559327612021 @default.
• W2555932761 countsByYear W25559327612022 @default.
• W2555932761 countsByYear W25559327612023 @default.
• W2555932761 crossrefType "journal-article" @default.
• W2555932761 hasAuthorship W2555932761A5001850476 @default.
• W2555932761 hasAuthorship W2555932761A5007165393 @default.
• W2555932761 hasAuthorship W2555932761A5007656302 @default.
• W2555932761 hasAuthorship W2555932761A5036246760 @default.
• W2555932761 hasAuthorship W2555932761A5069453585 @default.
• W2555932761 hasAuthorship W2555932761A5072775773 @default.
• W2555932761 hasAuthorship W2555932761A5075986086 @default.
• W2555932761 hasBestOaLocation W25559327611 @default.
• W2555932761 hasConcept C126322002 @default.
• W2555932761 hasConcept C134018914 @default.
• W2555932761 hasConcept C148762608 @default.
• W2555932761 hasConcept C169760540 @default.
• W2555932761 hasConcept C170493617 @default.
• W2555932761 hasConcept C25498285 @default.
• W2555932761 hasConcept C2778820722 @default.
• W2555932761 hasConcept C2781012912 @default.
• W2555932761 hasConcept C2781161787 @default.
• W2555932761 hasConcept C541997718 @default.
• W2555932761 hasConcept C61174792 @default.
• W2555932761 hasConcept C67018056 @default.
• W2555932761 hasConcept C71924100 @default.
• W2555932761 hasConcept C86803240 @default.
• W2555932761 hasConcept C98274493 @default.
• W2555932761 hasConceptScore W2555932761C126322002 @default.
• W2555932761 hasConceptScore W2555932761C134018914 @default.
• W2555932761 hasConceptScore W2555932761C148762608 @default.
• W2555932761 hasConceptScore W2555932761C169760540 @default.
• W2555932761 hasConceptScore W2555932761C170493617 @default.
• W2555932761 hasConceptScore W2555932761C25498285 @default.
• W2555932761 hasConceptScore W2555932761C2778820722 @default.
• W2555932761 hasConceptScore W2555932761C2781012912 @default.
• W2555932761 hasConceptScore W2555932761C2781161787 @default.
• W2555932761 hasConceptScore W2555932761C541997718 @default.
• W2555932761 hasConceptScore W2555932761C61174792 @default.
• W2555932761 hasConceptScore W2555932761C67018056 @default.
• W2555932761 hasConceptScore W2555932761C71924100 @default.
• W2555932761 hasConceptScore W2555932761C86803240 @default.

• next