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- W2555984955 abstract "Background: FeNO-guided asthma management resulted in 50% less exacerbations during pregnancy (Powell et al, Lancet 2011) and reduced the prevalence of recurrent bronchiolitis in the first year of life by 90% in their offspring (Mattes et al, Thorax 2014). Objectives: To assess asthma symptoms and diagnosis in a cohort of pre-schoolers born to mothers whose asthma treatment during pregnancy was guided either by symptoms (Clinical group), or FeNO and symptoms (FeNO group). Methods: We followed-up 109 of 146 children (75[PR1] %) seen at 12 months of age for preschool assessment. The ISAAC questionnaire, and interview ascertained symptoms were elicited, and lung function was measured using impulse oscillometry (IOS). Results: Mean age was 5.0 years (3.9-6.9) and 49% were male without difference between groups. Prevalence of wheeze ever (64% vs. 46%, p=0.05), frequent wheezing in the past 12 months (24% vs. 6%, p=0.01), doctor diagnosed asthma (42% vs. 21%, p=0.02) and ED visit for wheeze/asthma (20% vs. 2%, p=0.005) were all significantly lower in children from the FeNO group compared to the Clinical group. IOS was successful in 79 children (72%) and mean Z-score resistance at 5Hz (R5Hz) for children with wheeze ever was 0.74 (95% CI 0.41-1.08) compared to 0.18 (95% CI -0.08-0.43) without wheeze (p=0.01). Children with a doctor diagnosis of asthma had a mean R5Hz Z-score of 0.79 (95% CI 0.35-1.22) compared to 0.28 (95% CI 0.03-0.53, p=0.04) without asthma. No difference in R5Hz was observed between the Clinical and FeNO group. Conclusions: FeNO-guided management of asthma during pregnancy reduces respiratory symptoms and asthma diagnosis in the offspring at preschool age." @default.
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- W2555984955 date "2016-09-01" @default.
- W2555984955 modified "2023-09-27" @default.
- W2555984955 title "FeNO-guided management of asthma during pregnancy reduces respiratory symptoms and asthma diagnosis in childhood" @default.
- W2555984955 doi "https://doi.org/10.1183/13993003.congress-2016.pa330" @default.
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