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- W2556048986 abstract "Background: Behcet’s disease (BD) is a rare, immune-mediated small-vessel vasculitis involving multiple body systems. It is a chronic relapsing disease that can progress to neurological complications (neuro-Behcet’s disease; NBD) leading to cognitive impairment, but the extent of memory impairment in the early phase is poorly defined. Aim: To conduct a retrospective analysis of the relationship between duration of BD and impairment of memory function. Methods: Disease duration of BD was determined from medical records of 11 NBD patients. Following admission to our department, each patient completed two tests, the Revised Hasegawa Dementia Scale (HDS-R) and the Mini-mental state examination (MMSE), for evaluation of memory function. Results: Age at onset of BD was 39±15 years and age at neurological onset (NBD) was 42 ± 15 years, with a mean interval of 33 ± 36 months between the two. Two patients showed simultaneous onset of BD and NBD. After adjustment of HDS-R and MMSE scores for chronological age, we found that mean disease duration of BD (months) was negatively correlated with HDS-R score (p=0.03, r=-0.67), but not with MMSE score. Among the 11 NBD patients, there was no significant difference in mean HDS-R score between the 6 patients receiving methotrexate (MTX) therapy and the 5 patients not receiving MTX (all 11 patients were receiving prednisolone). In contrast, the mean MMSE score was lower in the group receiving MTX than in the group not receiving MTX (p<0.05). Conclusion: HDS-R scores were negatively correlated with disease duration of BD, and were not influenced by MTX therapy. Low scores in HDS-R, which includes items of short-term memory and verbal fluency (reflecting frontal lobe function), might be an early marker of progression of BD to NBD." @default.
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- W2556048986 date "2016-01-01" @default.
- W2556048986 modified "2023-09-27" @default.
- W2556048986 title "Impairment of Memory Function as a Marker of Progression from Behçet's Disease to Neuro- Behçet's Disease" @default.
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