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- W2556085760 endingPage "786" @default.
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- W2556085760 abstract "Head and neck squamous cell carcinoma (HNSCC) is one of the most common solid cancers worldwide. It is mainly caused by exposure to tobacco smoke and alcohol as well as infection with the human papilloma virus (HPV). The prognosis is poor, especially once it recurs or metastasizes. Current therapeutic options include surgery, radio- and chemotherapy. Epidermal growth factor receptor (EGFR) inhibitors are so far the only targeted agents that have been approved in head and neck cancer. Primary or secondary resistance is frequent or will eventually develop. Several driver mutations and other genomic aberrations have been described in HNSCC including <i>EGFR</i> overexpression and amplification. Yet, no predictive biomarkers for the application of EGFR inhibitors have been identified. Further targeted agents are in development for HNSCC, of which inhibitors of the PI3K pathway are the closest to clinical application. In recent years, the incidence of HPV-driven HNSCC has risen in Western countries. HPV-positive and -negative HNSCC are distinct molecular tumor entities, and consequences for targeted therapies have been discussed. This review looks at approved and investigational targeted treatment strategies as well as potential predictive biomarkers such as the HPV status to guide treatment." @default.
- W2556085760 created "2016-11-30" @default.
- W2556085760 creator A5006079706 @default.
- W2556085760 creator A5066640097 @default.
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- W2556085760 date "2016-01-01" @default.
- W2556085760 modified "2023-10-17" @default.
- W2556085760 title "Targeted Therapy of Head and Neck Cancer" @default.
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- W2556085760 cites W1757407923 @default.
- W2556085760 cites W1936230651 @default.
- W2556085760 cites W1971142107 @default.
- W2556085760 cites W1977307423 @default.
- W2556085760 cites W1981219430 @default.
- W2556085760 cites W1982403224 @default.
- W2556085760 cites W1985585626 @default.
- W2556085760 cites W1985850253 @default.
- W2556085760 cites W1986241711 @default.
- W2556085760 cites W1990956554 @default.
- W2556085760 cites W1997552014 @default.
- W2556085760 cites W1998971866 @default.
- W2556085760 cites W2004271732 @default.
- W2556085760 cites W2016794679 @default.
- W2556085760 cites W2037690883 @default.
- W2556085760 cites W2041919461 @default.
- W2556085760 cites W2054020870 @default.
- W2556085760 cites W2058118219 @default.
- W2556085760 cites W2062468721 @default.
- W2556085760 cites W2067224845 @default.
- W2556085760 cites W2067873262 @default.
- W2556085760 cites W2070705072 @default.
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- W2556085760 cites W2084461352 @default.
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- W2556085760 cites W2101027485 @default.
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- W2556085760 doi "https://doi.org/10.1159/000452432" @default.
- W2556085760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27889751" @default.
- W2556085760 hasPublicationYear "2016" @default.
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