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- W2556111075 endingPage "e0165138" @default.
- W2556111075 startingPage "e0165138" @default.
- W2556111075 abstract "Although our knowledge about Brucella virulence factors and the host response increase rapidly, the mechanisms of immune evasion by the pathogen and causes of chronic disease are still unknown. Here, we aimed to investigate the immunological factors which belong to CD8+ T cells and their roles in the transition of brucellosis from acute to chronic infection. Using miRNA microarray, more than 2000 miRNAs were screened in CD8+ T cells of patients with acute or chronic brucellosis and healthy controls that were sorted from peripheral blood with flow cytometry and validated through qRT-PCR. Findings were evaluated using GeneSpring GX (Agilent) 13.0 software and KEGG pathway analysis. Expression of two miRNAs were determined to display a significant fold change in chronic group when compared with acute or control groups. Both miRNAs (miR-126-5p and miR-4753-3p) were decreased (p <0.05 or fold change > 2). These miRNAs have the potential to be the regulators of CD8+ T cell-related marker genes for chronic brucellosis infections. The differentially expressed miRNAs and their predicted target genes are involved in MAPK signaling pathway, cytokine-cytokine receptor interactions, endocytosis, regulation of actin cytoskeleton, and focal adhesion indicating their potential roles in chronic brucellosis and its progression. It is the first study of miRNA expression analysis of human CD8+ T cells to clarify the mechanism of inveteracy in brucellosis." @default.
- W2556111075 created "2016-11-30" @default.
- W2556111075 creator A5018138910 @default.
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- W2556111075 creator A5062113953 @default.
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- W2556111075 creator A5081913600 @default.
- W2556111075 creator A5085937978 @default.
- W2556111075 creator A5089492553 @default.
- W2556111075 date "2016-11-08" @default.
- W2556111075 modified "2023-10-18" @default.
- W2556111075 title "MicroRNA Expression Patterns of CD8+ T Cells in Acute and Chronic Brucellosis" @default.
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